长链非编码RNA和环状RNA在川崎病中的作用：一项系统综述
Role of long non-coding RNAs and circular RNAs in kawasaki disease: a systematic review.
作者信息
Amirsardari Zahra, Abbasi Mohammadmahdi, Ahadi Shana, Rezaee Aida, Shalviri Alireza, Shavandi Farnaz, Alidousti Shahraki Reyhane, Mahdavi Mohammad, Malakootian Mahshid
机构信息
Cardiogenetic Research Center, Rajaie Cardiovascular Institute, Tehran, Iran.
School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
出版信息
Pediatr Rheumatol Online J. 2025 Jun 13;23(1):65. doi: 10.1186/s12969-025-01087-2.
OBJECTIVE
Previous research has identified the significant roles of non-coding RNAs (ncRNAs) in Kawasaki disease (KD). This systematic review aims to elucidate the involvement and significance of long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) in the pathogenesis and progression of KD.
STUDY DESIGN
A systematic search was conducted across four databases (PubMed, Embase, Scopus, and Web of Science) up to June 19, 2023, without year restrictions. The risk of bias was assessed using the Newcastle-Ottawa Scale.
RESULTS
This review included 9 studies encompassing a total of 1894 individuals diagnosed with KD. Seven lncRNAs-Slco4a1, SOCS2-AS1, SRA, HCG22, MHRT, XLOC_006277, and HSD11B1-AS1-were found to be associated with KD, including polymorphisms such as lncRNA rs1814343 C > T and AC008392.1 rs7248320. Additionally, four circRNAs-circRNA-3302, circ7632, circANRIL, and hsa_circ_0123996-were associated with KD.
CONCLUSIONS
Both linear lncRNAs and circRNAs play critical roles in unraveling the mechanisms underlying KD, contributing to biomarker identification and potential therapeutic advances.
目的
先前的研究已经确定了非编码RNA（ncRNAs）在川崎病（KD）中的重要作用。本系统评价旨在阐明长链非编码RNA（lncRNAs）和环状RNA（circRNAs）在KD发病机制和进展中的参与情况及意义。
研究设计
截至2023年6月19日，在四个数据库（PubMed、Embase、Scopus和Web of Science）中进行了无年份限制的系统检索。使用纽卡斯尔-渥太华量表评估偏倚风险。
结果
本评价纳入了9项研究，共1894例确诊为KD的个体。发现7种lncRNAs——Slco4a1、SOCS2-AS1、SRA、HCG22、MHRT、XLOC_006277和HSD11B1-AS1——与KD相关，包括lncRNA rs1814343 C>T和AC008392.1 rs7248320等多态性。此外，4种circRNAs——circRNA-3302、circ7632、circANRIL和hsa_circ_0123996——与KD相关。
结论
线性lncRNAs和circRNAs在揭示KD潜在机制方面均发挥关键作用，有助于生物标志物的识别和潜在的治疗进展。
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