Guo Suo, Xia Lan, Hu Rong, Wang Jing, Yang Peizeng
The First Affiliated Hospital of Chongqing Medical University, Chongqing Branch of National Clinical Research Center for Ocular Diseases, Chongqing, China; and.
Department of Ophthalmology, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.
Retina. 2025 Jan 1;45(1):79-87. doi: 10.1097/IAE.0000000000004259.
To characterize the changes in fundus corresponding to 120° field of view in chronic Vogt-Koyanagi-Harada disease in the quiescent phase and explore the associations with irreversible complications in the fundus using widefield swept-source optical coherence tomography angiography.
Prospective cross-sectional study. Sixty-nine patients with chronic Vogt-Koyanagi-Harada disease (115 eyes) and 55 healthy control subjects (110 eyes) were included and underwent widefield swept-source optical coherence tomography angiography. Univariate analyses of variations in retinal and choroidal vessel density (VD), choroidal volume, and choroidal vascularity index in patients with Vogt-Koyanagi-Harada with different disease durations and the control subjects were conducted. Logistic regression analysis was used to identify the associations with irreversible complications, including choroidal neovascularization, vasoproliferative tumor of the retina, and chorioretinal atrophy.
The Welch analysis of variance showed lower VD of superficial retina, deep retina, choriocapillaris, and large-sized and medium-sized vessels of the choroid, and choroidal volume and choroidal vascularity index in the patients with disease duration of >24 months compared with those with disease duration of ≤24 months (all P ≤ 0.011). The regression analysis revealed that the disease duration ( P = 0.008; OR = 1.02, 95% CI, 1.005-1.035) and VD of large-sized and medium-sized vessels of the choroid ( P = 0.001; OR = 0.707, 95% CI, 0.575-0.87) were significantly correlated with the irreversible complications.
Patients with chronic Vogt-Koyanagi-Harada in the quiescent phase with disease duration of >24 months exhibit more severe decreased VD in each layer of the retina and choroid, reduced choroidal volume, and sparse choroidal vascularity compared with those with disease duration ≤24 months. Prolonged duration and decreased VD of large-sized and medium-sized vessels of the choroid were associated with irreversible complications in the fundus.
通过超广角扫频源光学相干断层扫描血管造影术，描述静止期慢性Vogt-小柳原田病120°视野范围内眼底的变化，并探讨其与眼底不可逆并发症的相关性。
前瞻性横断面研究。纳入69例慢性Vogt-小柳原田病患者（115只眼）和55例健康对照者（110只眼），均接受超广角扫频源光学相干断层扫描血管造影术检查。对不同病程的Vogt-小柳原田病患者及对照者的视网膜和脉络膜血管密度（VD）、脉络膜体积及脉络膜血管化指数的变化进行单因素分析。采用逻辑回归分析确定其与包括脉络膜新生血管、视网膜血管增生性肿瘤及脉络膜视网膜萎缩在内的不可逆并发症的相关性。
方差分析显示，病程>24个月的患者与病程≤24个月的患者相比，其表浅视网膜、深层视网膜、脉络膜毛细血管以及脉络膜大、中血管的VD、脉络膜体积和脉络膜血管化指数均较低（均P≤0.011）。回归分析显示，病程（P = 0.008；OR = 1.02，95%CI，1.005 - 1.035）和脉络膜大、中血管的VD（P = 0.001；OR = 0.707，95%CI，0.575 - 0.87）与不可逆并发症显著相关。
与病程≤24个月的静止期慢性Vogt-小柳原田病患者相比，病程>24个月的患者视网膜和脉络膜各层的VD下降更严重，脉络膜体积减小，脉络膜血管稀疏。病程延长以及脉络膜大、中血管的VD降低与眼底不可逆并发症相关。
