使用扫频光学相干断层扫描血管造影术比较新生血管性、非新生血管性慢性中心性浆液性脉络膜视网膜病变病例与无症状对侧眼之间的微血管系统。

Comparison of microvasculature between neovascular, non-neovascular chronic central serous chorioretinopathy cases and asymptomatic fellow eyes using swept-source optical coherence tomography angiography.

作者信息

Soylu Ceren, Cebeci Zafer

机构信息

Department of Ophthalmology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.

Doheny Eye Institute, Pasadena, California, USA.

出版信息

Int Ophthalmol. 2025 Jul 18;45(1):297. doi: 10.1007/s10792-025-03673-5.

DOI:10.1007/s10792-025-03673-5

PMID:40679632

Abstract

PURPOSE

To compare microvasculature changes between neovascular, non-neovascular chronic central serous chorioretinopathy cases (cCSCR) and asymptomatic fellow eyes using swept-source optical coherence tomography angiography (SS-OCTA).

METHODS

Medical records of 70 treatment-naïve patients with chronic central serous chorioretinopathy (cCSCR) who had undergone spectral-domain optical coherence tomography (SD-OCT) and SS-OCTA were reviewed. Among 132 eyes, 81 were diagnosed with cCSCR, 51 eyes were included as asymptomatic fellow eyes. Eyes diagnosed with cCSCR were divided into two groups based on the presence of choroidal neovascularization (CNV) in outer retinal slab on OCTA. There were 3 groups: CNV (+), CNV (-) cCSCR and asymptomatic fellow eyes. Vessel density (VD) in macular region was measured in automatically segmented superficial capillary plexus (SCP), deep capillary plexus (DCP) and choriocapillaris (CC) slabs and compared between these 3 groups.

RESULTS

Mean age of cCSCR patients was 55,83 ± 8,55 years. In 81 eyes diagnosed with cCSCR, 27 eyes were CNV (+) and 54 eyes were CNV (-) on OCTA. Patients with CNV (+) on OCTA were significantly older than CNV (-) patients (p < 0.05). CNV (+) patients' best- corrected visual acuity (BCVA) was significantly lower than CNV (-) patients (p < 0.01). Subfoveal choroidal thickness (SFCT) of CNV (+) eyes was significantly lower than CNV (-) eyes (p < 0.01). Foveal SCP VD and CC VD of CNV (+) and CNV (-) eyes were significantly lower than asymptomatic fellow eyes (p < 0.05). Foveal DCP VD of CNV (+) and CNV (-) eyes was significantly higher than asymptomatic fellow eyes (p < 0.05). Foveal, parafoveal superior and temporal CC VD of CNV (+) eyes was significantly lower than CNV (-) eyes (p < 0.05).

CONCLUSIONS

Retinal and choroidal microcirculation difference between neovascular and non-neovascular cCSCR eyes may be an indicator of ischemia, therefore a contributing factor in neovascularization development.

摘要

目的

使用扫频源光学相干断层扫描血管造影（SS-OCTA）比较新生血管性和非新生血管性慢性中心性浆液性脉络膜视网膜病变（cCSCR）病例与无症状对侧眼之间的微血管变化。

方法

回顾了70例未经治疗的慢性中心性浆液性脉络膜视网膜病变（cCSCR）患者的病历，这些患者均接受了光谱域光学相干断层扫描（SD-OCT）和SS-OCTA检查。在132只眼中，81只被诊断为cCSCR，51只眼作为无症状对侧眼纳入研究。根据OCTA在外视网膜层是否存在脉络膜新生血管（CNV），将诊断为cCSCR的眼分为两组。共有3组：CNV（+）组、CNV（-）组cCSCR和无症状对侧眼。在自动分割的浅表毛细血管丛（SCP）、深部毛细血管丛（DCP）和脉络膜毛细血管（CC）层测量黄斑区的血管密度（VD），并在这3组之间进行比较。

结果

cCSCR患者的平均年龄为55.83±8.55岁。在81只诊断为cCSCR的眼中，OCTA显示27只眼为CNV（+），54只眼为CNV（-）。OCTA显示CNV（+）的患者比CNV（-）的患者年龄显著更大（p<0.05）。CNV（+）患者的最佳矫正视力（BCVA）显著低于CNV（-）患者（p<0.01）。CNV（+）眼的黄斑下脉络膜厚度（SFCT）显著低于CNV（-）眼（p<0.01）。CNV（+）和CNV（-）眼的黄斑区SCP VD和CC VD显著低于无症状对侧眼（p<0.05）。CNV（+）和CNV（-）眼的黄斑区DCP VD显著高于无症状对侧眼（p<0.05）。CNV（+）眼的黄斑、黄斑旁上方和颞侧CC VD显著低于CNV（-）眼（p<0.05）。