甲状腺功能减退性桥本甲状腺炎中的甲状腺素、甲巯咪唑及甲状腺微粒体自身抗体滴度
Thyroxine, methimazole, and thyroid microsomal autoantibody titres in hypothyroid Hashimoto's thyroiditis.
作者信息
Jansson R, Karlsson A, Dahlberg P A
出版信息
Br Med J (Clin Res Ed). 1985 Jan 5;290(6461):11-2. doi: 10.1136/bmj.290.6461.11.
Abstract
Ten hypothyroid patients with Hashimoto's thyroiditis were treated with methimazole 30 mg in addition to thyroxine 0.15 mg daily. Another 10 hypothyroid patients with Hashimoto's thyroiditis were given thyroxine 0.15 mg alone. After 22 weeks of treatment significant decreases in thyroid microsomal autoantibody titres were observed in both groups (p less than 0.01). There was no difference in the mean change in titre between the two groups. When the patients treated with methimazole were subsequently given thyroxine 0.15 mg alone for a further 22 weeks no additional change in titre was observed. The data suggest that thyroxine, by normalising serum thyroid stimulating hormone concentrations, may reduce the autoantigenic properties of the thyrocytes with a subsequent decrease in autoantibody titres.
摘要
10名患有桥本甲状腺炎的甲状腺功能减退患者，除每日服用0.15毫克甲状腺素外，还服用30毫克甲巯咪唑。另外10名患有桥本甲状腺炎的甲状腺功能减退患者仅服用0.15毫克甲状腺素。治疗22周后，两组患者的甲状腺微粒体自身抗体滴度均显著下降（p<0.01）。两组之间滴度的平均变化没有差异。当用甲巯咪唑治疗的患者随后再单独服用0.15毫克甲状腺素22周时，未观察到滴度有额外变化。数据表明，甲状腺素通过使血清促甲状腺激素浓度正常化，可能会降低甲状腺细胞的自身抗原特性，随后自身抗体滴度会下降。
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Comparative bioavailability of carbimazole and methimazole.卡比马唑和甲巯咪唑的相对生物利用度。
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Methimazole and generation of oxygen radicals by monocytes: potential role in immunosuppression.甲巯咪唑与单核细胞产生氧自由基：在免疫抑制中的潜在作用。
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