卡比马唑与桥本甲状腺炎中的自身抗体合成
Carbimazole and autoantibody synthesis in Hashimoto's thyroiditis.
作者信息
McGregor A M, Ibbertson H K, Smith B R, Hall R
出版信息
Br Med J. 1980 Oct 11;281(6246):968-9. doi: 10.1136/bmj.281.6246.968.
Abstract
Serum thyroxine, thyrotrophin, and thyroid microsomal antibody levels were measured in 20 patients with Hashimoto's thyroiditis and hypothyroidism before, during, and after treatment with carbimazole or placebo. Thyroid microsomal antibody levels fell during treatment in the 10 patients who received carbimazole, while serum thyroxine and thyrotrophin levels did not change. There were no changes in the placebo group. The study proves support for the concept that carbimazole may act directly on autoantibody synthesising lymphocytes localised in the thyroid. Such an effect might be valuable in influencing the autoimmune process in autoimmune thyroid disease.
摘要
对20例患有桥本甲状腺炎并伴有甲状腺功能减退的患者，在使用卡比马唑或安慰剂治疗前、治疗期间及治疗后，测定了血清甲状腺素、促甲状腺激素和甲状腺微粒体抗体水平。在接受卡比马唑治疗的10例患者中，治疗期间甲状腺微粒体抗体水平下降，而血清甲状腺素和促甲状腺激素水平未发生变化。安慰剂组则无变化。该研究证实了卡比马唑可能直接作用于甲状腺内合成自身抗体的淋巴细胞这一观点。这种作用可能对影响自身免疫性甲状腺疾病的自身免疫过程具有重要价值。
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