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乳腺癌术后急性和持续性疼痛:三级医院队列的描述性研究。

Acute and persistent post-operative pain following mastectomy: a descriptive study in a tertiary hospital cohort.

机构信息

Provisional Fellow, Department of Anaesthesia, Dunedin Hospital, Dunedin.

Anaesthetic registrar, Department of Anaesthesia, Dunedin Hospital, Dunedin.

出版信息

N Z Med J. 2024 Aug 23;137(1601):36-47. doi: 10.26635/6965.6524.

Abstract

AIMS

Post mastectomy pain syndrome (PMPS) can have significant negative effects on patients' quality of life after mastectomy. The estimated prevalence of PMPS varies widely and there is little data from a New Zealand population. This limits clinicians' ability to meaningfully describe and discuss pain-related complications of mastectomy peri-operatively.

METHOD

We designed a single-centre, retrospective study to describe acute post-operative analgesic requirements after mastectomy, to describe the prevalence of PMPS at least 1 year after surgery, and to identify associated risk factors for this complication.

RESULTS

One hundred and thirty mastectomy patients met inclusion criteria and 59 were willing and able to participate in 12-month follow-up. Acute post-operative pain was generally well managed with modest doses of oral analgesics. Sixty-six percent (n=39) of women reported some form of persistent pain symptoms post-mastectomy; this was associated with younger age, axillary surgery and chemotherapy. Only 5% of patients (n=3) met consensus criteria for PMPS, which limited identification of risk factors for this more severe complication.

CONCLUSION

Despite PMPS occurring infrequently, post-operative pain of a less severe nature after mastectomy occurs commonly. Clinicians should remain vigilant to possible risk factors for this post-operative complication and counsel patients appropriately.

摘要

目的

乳腺癌根治术后疼痛综合征(PMPS)可对患者术后生活质量产生显著负面影响。PMPS 的估计患病率差异很大,来自新西兰人群的数据很少。这限制了临床医生在围手术期有意义地描述和讨论与疼痛相关的乳腺癌根治术并发症的能力。

方法

我们设计了一项单中心回顾性研究,以描述乳腺癌根治术后急性术后镇痛需求,描述术后至少 1 年 PMPS 的患病率,并确定该并发症的相关危险因素。

结果

130 名乳腺癌根治术患者符合纳入标准,其中 59 名愿意并能够参加 12 个月随访。急性术后疼痛通常通过适度剂量的口服镇痛药得到很好的控制。66%(n=39)的女性报告在乳腺癌根治术后存在某种形式的持续性疼痛症状;这与年龄较小、腋窝手术和化疗有关。仅有 5%的患者(n=3)符合 PMPS 的共识标准,这限制了对这种更严重并发症的危险因素的识别。

结论

尽管 PMPS 很少见,但乳腺癌根治术后仍常出现程度较轻的术后疼痛。临床医生应警惕这种术后并发症的可能危险因素,并适当为患者提供咨询。

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