Department of Histology and Embryology, School of Preclinical Medical, Zunyi Medical University, Zunyi, Guizhou, China.
Department of Histology and Embryology, School of Preclinical Medical, Zunyi Medical University, Zunyi, Guizhou, China; Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, China.
J Reprod Immunol. 2024 Sep;165:104314. doi: 10.1016/j.jri.2024.104314. Epub 2024 Aug 8.
To confirm the causal relationship between immune cells and Ovarian Hyperstimulation Syndrome.
Obtaining data, collecting single nucleotide polymorphisms, detecting instrumental variables heterogeneity, assessing causality, and assessing bidirectional causality.
A two sample Mendelian study to confirm the causal relationship between immune cells and Ovarian Hyperstimulation Syndrome.
Immune cell phenotype (including 22 million SNPs from GWAS on 3757 European individuals).
Inverse variance weighting, one-sample analysis, MR-Egger, weighted median and weighted mode are used to assess the causal relationship between 731 immunophenotypes and Ovarian Hyperstimulation Syndrome. The weighted median and Mendelian Randomization multi-effect residuals and Mendelian Randomization multi-effect residuals and outlier tests are used to assess bidirectional causality between this two.
After False Discovery Rate correction, 9 immunophenotypes were found to be significantly associated with the risk of Ovarian Hyperstimulation Syndrome. B cell panel: IgD+ AC (OR, 0.90) 、CD19 on CD24+ CD27+ (OR, 0.86) 、BAFF-R on CD20- CD38 (OR, -1.22); Mature T cell group panel: EM DN (CD4 -CD8-) AC (OR, 1.46); Myeloid cell panel: Mo MDSC AC (OR, 1.13) 、CD45 on CD33br HLA-DR+ (OR, 0.87); Monocyte panel: HLA-DR on monocyte (OR, 0.86) 、CCR2 on CD14+ CD16+ monocyte (OR, 1.15) 、cDC panel: HLA-DR on myeloid DC (OR, 0.89).
This study shows the potential link between OHSS and immune cells by genetic means, providing new ideas for future clinical and basic research.
确认免疫细胞与卵巢过度刺激综合征之间的因果关系。
获取数据，收集单核苷酸多态性，检测工具变量异质性，评估因果关系，并评估双向因果关系。
一项两样本孟德尔研究，以确认免疫细胞与卵巢过度刺激综合征之间的因果关系。
免疫细胞表型（包括来自 3757 名欧洲个体的 GWAS 的 2200 万个 SNP）。
使用逆方差加权、单样本分析、MR-Egger、加权中位数和加权众数评估 731 种免疫表型与卵巢过度刺激综合征之间的因果关系。使用加权中位数和孟德尔随机化多效残差以及孟德尔随机化多效残差和异常值检验评估这两者之间的双向因果关系。
在经过错误发现率校正后，发现 9 种免疫表型与卵巢过度刺激综合征的风险显著相关。B 细胞谱：IgD+AC（OR，0.90）、CD19 在 CD24+CD27+（OR，0.86）、BAFF-R 在 CD20-CD38（OR，-1.22）；成熟 T 细胞组谱：EM DN（CD4-CD8-）AC（OR，1.46）；髓样细胞谱：Mo MDSC AC（OR，1.13）、CD33br HLA-DR+上的 CD45（OR，0.87）；单核细胞谱：单核细胞上的 HLA-DR（OR，0.86）、CD14+CD16+单核细胞上的 CCR2（OR，1.15）、cDC 谱：髓样 DC 上的 HLA-DR（OR，0.89）。
本研究通过遗传手段显示了 OHSS 与免疫细胞之间的潜在联系，为未来的临床和基础研究提供了新的思路。
