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1
Fever of unexplained origin, biochemical Cushing's disease and cerebral dysrhythmia corrected by valproate sodium.不明原因发热、生化性库欣病及丙戊酸钠纠正的脑节律异常。
Can Med Assoc J. 1985 Jan 15;132(2):150-4.
2
[Clinical remission in Cushing's disease through treatment with sodium valproate and bromocriptine].[通过丙戊酸钠和溴隐亭治疗实现库欣病的临床缓解]
Rev Clin Esp. 1991 Jan;188(1):37-40.
3
Sodium valproate and heterogeneity of pituitary dependent Cushing's syndrome.丙戊酸钠与垂体依赖性库欣综合征的异质性
Lancet. 1982 May 29;1(8283):1253. doi: 10.1016/s0140-6736(82)92383-2.
4
Sodium valproate and cyproheptadine may independently induce a remission in the same patient with Cushing's disease.丙戊酸钠和赛庚啶可能分别使同一例库欣病患者病情缓解。
Acta Endocrinol (Copenh). 1983 Oct;104(2):160-3. doi: 10.1530/acta.0.1040160.
5
Cyclical Cushing's disease and its successful control under sodium valproate.周期性库欣病及其在丙戊酸钠治疗下的成功控制
J Endocrinol Invest. 1990 Dec;13(11):923-9. doi: 10.1007/BF03349657.
6
Valproate in Cushing's syndrome.库欣综合征中的丙戊酸盐。
Lancet. 1982 Jan 16;1(8264):171. doi: 10.1016/s0140-6736(82)90422-6.
7
Sodium valproate in Cushing's disease.丙戊酸钠治疗库欣病
Lancet. 1984 Jul 21;2(8395):162-3. doi: 10.1016/s0140-6736(84)91074-2.
8
Glucocorticoid action and the clinical features of Cushing's syndrome.糖皮质激素作用与库欣综合征的临床特征。
Endocrinol Metab Clin North Am. 1994 Sep;23(3):487-509.
9
Cushing's disease. A review.库欣病。综述。
Arch Intern Med. 1985 Jun;145(6):1106-11.
10
Profound amplification of secretory-burst mass and anomalous regularity of ACTH secretory process in patients with Nelson's syndrome compared with Cushing's disease.与库欣病相比，尼尔森综合征患者的分泌突发量显著增加且促肾上腺皮质激素分泌过程异常规律。
Clin Endocrinol (Oxf). 2004 Jun;60(6):765-72. doi: 10.1111/j.1365-2265.2004.02052.x.

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Tests of pituitary-adrenal suppressibility in the diagnosis of Cushing's syndrome.垂体-肾上腺抑制试验在库欣综合征诊断中的应用
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The determination of 17,21-dihydroxy-20-ketosteroids in urine and plasma.尿液和血浆中17,21 - 二羟基 - 20 - 酮类固醇的测定
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Drug therapy: Valproic acid.药物治疗：丙戊酸。
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The evaluation of sodium valproate in the treatment of Nelson's syndrome.
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GABA neuron systems in hypothalamus and the pituitary gland. Immunohistochemical demonstration using antibodies against glutamate decarboxylase.下丘脑和垂体中的γ-氨基丁酸（GABA）神经元系统。使用抗谷氨酸脱羧酶抗体的免疫组织化学证明。
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gamma-Aminobutyric acid- and benzodiazepine-binding sites in human anterior pituitary tissue.人垂体前叶组织中的γ-氨基丁酸和苯二氮䓬结合位点
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Effects of valproic acid, naloxone and hydrocortisone in Nelson's syndrome and cushing's disease.丙戊酸、纳洛酮和氢化可的松对尼尔森综合征和库欣病的影响。
Clin Endocrinol (Oxf). 1981 Aug;15(2):151-4. doi: 10.1111/j.1365-2265.1981.tb00649.x.
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Spontaneous remission of Cushing's disease. Report of a case.库欣病的自发缓解。病例报告。
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A radioimmunoassay for measurement of thyroxine in unextracted serum.一种用于测量未提取血清中甲状腺素的放射免疫分析方法。
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不明原因发热、生化性库欣病及丙戊酸钠纠正的脑节律异常。

Fever of unexplained origin, biochemical Cushing's disease and cerebral dysrhythmia corrected by valproate sodium.

作者信息

López-Moreno J M, Rodríguez-Portales J A, Mahana D

出版信息

Can Med Assoc J. 1985 Jan 15;132(2):150-4.

PMID:3917350
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1346744/
Abstract

A patient with cerebral dysrhythmia and fever of unexplained origin for 2 years is described. She had elevated and nonsuppressible levels of urinary 17-hydroxycorticosteroids but no clinical features of hypercortisolism. Treatment with valproate sodium corrected all the abnormalities. It is postulated that cerebral dysrhythmia can affect the hypothalamic mechanisms of body temperature and regulation of adrenocorticotropic hormone levels.

摘要

本文描述了一名患有大脑节律异常和不明原因发热2年的患者。她的尿17-羟皮质类固醇水平升高且不可抑制，但没有库欣综合征的临床特征。丙戊酸钠治疗纠正了所有异常情况。据推测，大脑节律异常可能影响体温的下丘脑机制以及促肾上腺皮质激素水平的调节。