Schmid H
Dev Biol. 1985 Jan;107(1):28-37. doi: 10.1016/0012-1606(85)90372-0.
The effects of homeotic mutations on transdetermination in eye-antenna imaginal discs of Drosophila melanogaster were studied. After 12 days of culture in vivo, antenna discs transformed to ventral mesothorax by AntpNs or AntpZ, transdetermined to notum and wing structures four to five times more frequently than the corresponding wild-type antenna discs. Likewise, eye discs transformed to dorsal mesothorax by eyopt transdetermined to leg structures, also extremely frequently (90%). It seems that, during culture, homeotic antenna as well as homeotic eye discs tend to complete the structural inventory of the mesothoracic segment. Transdetermination in the homeotic disc parts is interpreted as a regeneration process which reestablishes an entire segment, i.e., the ventral mesothoracic portion (leg) in the antenna disc regenerates dorsal mesothoracic parts, and the dorsal mesothoracic portion in the eye disc (wing) regenerates ventral mesothoracic parts, respectively. This implies that antenna and leg discs (ventral qualities) as well as eye and wing discs (dorsal qualities) are serially homologous. The transdetermination frequency of the untransformed eye disc to notum and wing structures is enhanced by Antp to the same extent as is the transdetermination frequency of the antenna disc. The first allotypic wing disc structure formed by the eye disc is notum, followed by structures of the anterior wing compartment and finally by posterior wing structures. No evidence for such a sequence was found in the transdetermination pattern of the antenna disc.
研究了同源异型突变对黑腹果蝇眼触角成虫盘转决定的影响。在体内培养12天后，通过AntpNs或AntpZ转化为腹侧中胸的触角盘，其转决定为背板和翅结构的频率比相应的野生型触角盘高4至5倍。同样，通过eyopt转化为背侧中胸的眼盘也极频繁地（90%）转决定为腿结构。似乎在培养过程中，同源异型触角盘以及同源异型眼盘倾向于完成中胸节段的结构组成。同源异型盘部分的转决定被解释为一个再生过程，该过程重新建立一个完整的节段，即触角盘中腹侧中胸部分（腿）再生背侧中胸部分，而眼盘中背侧中胸部分（翅）分别再生腹侧中胸部分。这意味着触角盘和腿盘（腹侧特征）以及眼盘和翅盘（背侧特征）是连续同源的。Antp将未转化的眼盘转决定为背板和翅结构的频率提高到与触角盘转决定频率相同的程度。眼盘形成的第一个异型翅盘结构是背板，接着是前翅区结构，最后是后翅结构。在触角盘的转决定模式中未发现这种序列的证据。
