Department of Biomedical and Clinical Sciences, University of Milan, Milan, Italy.
IRCCS Fondazione Don Carlo Gnocchi ONLUS, Milan, Italy.
Nat Commun. 2024 Aug 22;15(1):7207. doi: 10.1038/s41467-024-51586-1.
By connecting old and recent notions, different spatial scales, and research domains, we introduce a novel framework on the consequences of brain injury focusing on a key role of slow waves. We argue that the long-standing finding of EEG slow waves after brain injury reflects the intrusion of sleep-like cortical dynamics during wakefulness; we illustrate how these dynamics are generated and how they can lead to functional network disruption and behavioral impairment. Finally, we outline a scenario whereby post-injury slow waves can be modulated to reawaken parts of the brain that have fallen asleep to optimize rehabilitation strategies and promote recovery.
通过连接旧的和新的概念、不同的空间尺度和研究领域，我们引入了一个关于脑损伤后果的新框架，该框架侧重于慢波的关键作用。我们认为，脑损伤后脑电图慢波的长期发现反映了睡眠样皮质动力学在清醒状态下的入侵；我们说明了这些动力学是如何产生的，以及它们如何导致功能网络中断和行为障碍。最后，我们概述了一种方案，即通过调节损伤后慢波，可以唤醒已经入睡的大脑部分，以优化康复策略并促进恢复。
