• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Optimal Timing of PD-1/PD-L1 Blockade Protects Organ Function During Sepsis.

作者信息

Xiang Jing, Wang Yuanyang, Shi Langtian, Qiu Jinchao, Gan Lebin, Xu Zhe, Zhang Huacai, Deng Jin, Wang Zhen, Xu Fang, Zeng Ling

机构信息

Department of Critical Care Medicine, the First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China.

Department of Trauma Medical Center, Daping Hospital, State Key Laboratory of Trauma and Chemical Poisoning, Burns and Combined Injury, Army Medical University, Chongqing, 400042, China.

出版信息

Inflammation. 2024 Aug 23. doi: 10.1007/s10753-024-02113-3.

DOI:10.1007/s10753-024-02113-3
PMID:39174864
Abstract
摘要

相似文献

1
Optimal Timing of PD-1/PD-L1 Blockade Protects Organ Function During Sepsis.PD-1/PD-L1阻断的最佳时机可在脓毒症期间保护器官功能。
Inflammation. 2024 Aug 23. doi: 10.1007/s10753-024-02113-3.
2
Lymphocyte subset expression and serum concentrations of PD-1/PD-L1 in sepsis - pilot study.淋巴细胞亚群表达与脓毒症 PD-1/PD-L1 血清浓度的关系 - 一项初步研究。
Crit Care. 2018 Apr 17;22(1):95. doi: 10.1186/s13054-018-2020-2.
3
PD-L1 Blockade Improves Survival in Sepsis by Reversing Monocyte Dysfunction and Immune Disorder.PD-L1 阻断通过逆转单核细胞功能障碍和免疫紊乱改善脓毒症患者的生存。
Inflammation. 2024 Feb;47(1):114-128. doi: 10.1007/s10753-023-01897-0. Epub 2023 Sep 30.
4
PD-L1 blockade improves survival in experimental sepsis by inhibiting lymphocyte apoptosis and reversing monocyte dysfunction.PD-L1 阻断通过抑制淋巴细胞凋亡和逆转单核细胞功能障碍来改善实验性败血症的生存。
Crit Care. 2010;14(6):R220. doi: 10.1186/cc9354. Epub 2010 Nov 30.
5
Lactic acid inhibits the interaction between PD-L1 protein and PD-L1 antibody in the PD-1/PD-L1 blockade therapy-resistant tumor.乳酸在PD-1/PD-L1阻断治疗耐药的肿瘤中抑制PD-L1蛋白与PD-L1抗体之间的相互作用。
Mol Ther. 2025 Feb 5;33(2):723-733. doi: 10.1016/j.ymthe.2024.12.044. Epub 2024 Dec 31.
6
Frontline Science: Anti-PD-L1 protects against infection with common bacterial pathogens after burn injury.前沿科学：抗 PD-L1 可预防烧伤感染常见细菌病原体。
J Leukoc Biol. 2018 Jan;103(1):23-33. doi: 10.1002/JLB.5HI0917-360R. Epub 2017 Dec 21.
7
Management of Adverse Events in Cancer Patients Treated With PD-1/PD-L1 Blockade: Focus on Asian Populations.接受PD-1/PD-L1阻断治疗的癌症患者不良事件的管理：聚焦亚洲人群。
Front Pharmacol. 2019 Jul 2;10:726. doi: 10.3389/fphar.2019.00726. eCollection 2019.
8
Elucidating the role of N-myristoylation in the excessive membrane localization of PD-L1 in hypoxic cancers and developing a novel NMT1 inhibitor for combination with immune checkpoint blockade therapy.阐明N-肉豆蔻酰化在缺氧癌症中程序性死亡受体配体1（PD-L1）过度膜定位中的作用，并开发一种新型N-肉豆蔻酰转移酶1（NMT1）抑制剂，用于与免疫检查点阻断疗法联合使用。
J Exp Clin Cancer Res. 2025 Jul 2;44(1):181. doi: 10.1186/s13046-025-03438-z.
9
Addition of immunotherapy to chemotherapy for metastatic triple-negative breast cancer: A systematic review and meta-analysis of randomized clinical trials.免疫疗法联合化疗治疗转移性三阴性乳腺癌：随机临床试验的系统评价和荟萃分析。
Crit Rev Oncol Hematol. 2021 Dec;168:103530. doi: 10.1016/j.critrevonc.2021.103530. Epub 2021 Nov 18.
10
Therapeutic targeting of the p300/CBP bromodomain enhances the efficacy of immune checkpoint blockade therapy.p300/CBP 溴结构域的治疗性靶向增强了免疫检查点阻断疗法的疗效。
Oncogene. 2025 Apr 21. doi: 10.1038/s41388-025-03417-w.

本文引用的文献

1
PD-L1 Blockade Improves Survival in Sepsis by Reversing Monocyte Dysfunction and Immune Disorder.PD-L1 阻断通过逆转单核细胞功能障碍和免疫紊乱改善脓毒症患者的生存。
Inflammation. 2024 Feb;47(1):114-128. doi: 10.1007/s10753-023-01897-0. Epub 2023 Sep 30.
2
generated butyrate boosts anti-PD-1 efficacy in colorectal cancer by activating cytotoxic CD8 T cells.产生的丁酸盐通过激活细胞毒性 CD8 T 细胞来提高结直肠癌的抗 PD-1 疗效。
Gut. 2023 Nov;72(11):2112-2122. doi: 10.1136/gutjnl-2023-330291. Epub 2023 Jul 25.
3
Transformable prodrug nanoplatform tumor microenvironment modulation and immune checkpoint blockade potentiates immunogenic cell death mediated cancer immunotherapy.
可变形前药纳米平台调节肿瘤微环境和免疫检查点阻断增强免疫原性细胞死亡介导的癌症免疫治疗。
Theranostics. 2023 Mar 21;13(6):1906-1920. doi: 10.7150/thno.83912. eCollection 2023.
4
Expert consensus on the monitoring and treatment of sepsis-induced immunosuppression.脓毒症导致免疫抑制监测与治疗的专家共识。
Mil Med Res. 2022 Dec 26;9(1):74. doi: 10.1186/s40779-022-00430-y.
5
Sepsis-induced immunosuppression: mechanisms, diagnosis and current treatment options.脓毒症导致的免疫抑制：机制、诊断和当前治疗选择。
Mil Med Res. 2022 Oct 9;9(1):56. doi: 10.1186/s40779-022-00422-y.
6
Tim-3 regulates sepsis-induced immunosuppression by inhibiting the NF-κB signaling pathway in CD4 T cells.Tim-3 通过抑制 CD4 T 细胞中的 NF-κB 信号通路来调节脓毒症引起的免疫抑制。
Mol Ther. 2022 Mar 2;30(3):1227-1238. doi: 10.1016/j.ymthe.2021.12.013. Epub 2021 Dec 18.
7
Sepsis-Induced Immunosuppression.脓毒症导致的免疫抑制。
Annu Rev Physiol. 2022 Feb 10;84:157-181. doi: 10.1146/annurev-physiol-061121-040214. Epub 2021 Oct 27.
8
Upregulated PD-L1 delays human neutrophil apoptosis and promotes lung injury in an experimental mouse model of sepsis.在脓毒症实验小鼠模型中，上调的程序性死亡配体1（PD-L1）会延迟人中性粒细胞凋亡并促进肺损伤。
Blood. 2021 Sep 2;138(9):806-810. doi: 10.1182/blood.2020009417.
9
Injectable Supramolecular Hydrogel for Locoregional Immune Checkpoint Blockade and Enhanced Cancer Chemo-Immunotherapy.用于局部区域免疫检查点阻断和增强癌症化学免疫治疗的可注射超分子水凝胶
ACS Appl Mater Interfaces. 2021 Jul 28;13(29):33874-33884. doi: 10.1021/acsami.1c08285. Epub 2021 Jul 19.
10
Trends in peptide drug discovery.肽类药物研发趋势。
Nat Rev Drug Discov. 2021 Apr;20(4):309-325. doi: 10.1038/s41573-020-00135-8. Epub 2021 Feb 3.