Faculdade de Ciências Aplicadas, Universidade Estadual de Campinas (FCA/UNICAMP), Limeira, São Paulo, Brazil.
Department of Biotechnologies, BiomeHub, Florianópolis, Santa Catarina, Brazil.
Physiol Rep. 2024 Aug;12(16):e70017. doi: 10.14814/phy2.70017.
Obesity is characterized by specific changes in the composition of the gut microbiota (GM). Exercise can contribute to the modulation of GM. This is the first case study to analyze the composition and metabolism of the GM of an obese runner in a single-stage mountain ultramarathon (MUM) with a mileage of 217 km. Fecal samples were collected 7 days before the race (T0), 15 min after the end of the race (T1), and 7 days after the end of the race (T2). GM composition was analyzed by real-time PCR and shotgun sequencing. We observed a decrease in Bacillota/Bacteroidota ratio and α-diversity after the race. After the 217-km MUM, we observed a decrease in symbiont microorganisms and a notable increase in harmful bacteria. In conclusion, we found that the 217-km MUM may have contributed to the intestinal dysbiosis of the obese runner.
肥胖的特征是肠道微生物组（GM）的组成发生了特定的变化。运动可以有助于调节 GM。这是首例在单阶段山地超马（MUM）中分析肥胖跑步者 GM 的组成和代谢的案例研究，MUM 的里程为 217 公里。在比赛前 7 天（T0）、比赛结束后 15 分钟（T1）和比赛结束后 7 天（T2）采集粪便样本。通过实时 PCR 和鸟枪法测序分析 GM 组成。我们观察到比赛后 Bacillota/Bacteroidota 比值和 α-多样性下降。在 217 公里 MUM 后，我们观察到共生微生物减少，有害细菌明显增加。总之，我们发现 217 公里 MUM 可能导致肥胖跑步者的肠道菌群失调。
