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动物健康实验室中的质谱技术：历史回顾、当前应用和未来方向。

Mass spectrometry in animal health laboratories: recent history, current applications, and future directions.

机构信息

California Animal Health and Food Safety Laboratory, University of California-Davis, Davis, CA, USA.

出版信息

J Vet Diagn Invest. 2024 Nov;36(6):777-789. doi: 10.1177/10406387241270071. Epub 2024 Aug 22.

DOI:10.1177/10406387241270071
PMID:39175303
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11529146/
Abstract

Mass spectrometry (MS) has long been considered a cornerstone technique in analytical chemistry. However, the use of MS in animal health laboratories (AHLs) has been limited, however, largely because of the expense involved in purchasing and maintaining these systems. Nevertheless, since ~2020, the use of MS techniques has increased significantly in AHLs. As expected, developments in new instrumentation have shown significant benefits in veterinary analytical toxicology as well as bacteriology. Creative researchers continue to push the boundaries of MS analysis, and MS now promises to impact disciplines other than toxicology and bacteriology. I include a short discussion of MS instrumentation, more detailed discussions of the MS techniques introduced since ~2020, and a variety of new techniques that promise to bring the benefits of MS to disciplines such as virology and pathology.

摘要

质谱（MS）长期以来一直被认为是分析化学的基石技术。然而，MS 在动物健康实验室（AHL）中的应用受到限制，主要是因为购买和维护这些系统涉及到费用。然而，自 2020 年以来，MS 技术在 AHL 中的应用显著增加。正如预期的那样，新仪器的发展在兽医分析毒理学和细菌学方面显示出了显著的好处。有创造力的研究人员继续推动 MS 分析的边界，而 MS 现在有望影响毒理学和细菌学以外的学科。我将简短讨论一下 MS 仪器，更详细地讨论一下自 2020 年以来引入的 MS 技术，以及各种新的技术，这些技术有望将 MS 的优势引入病毒学和病理学等学科。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a796/11529146/fee2a22af192/10.1177_10406387241270071-fig8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a796/11529146/54b79a0bb1fb/10.1177_10406387241270071-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a796/11529146/7e6c41b2662f/10.1177_10406387241270071-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a796/11529146/17fbe5f27445/10.1177_10406387241270071-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a796/11529146/4b3893ebaed3/10.1177_10406387241270071-fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a796/11529146/1a541da3bc64/10.1177_10406387241270071-fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a796/11529146/659716d68fc9/10.1177_10406387241270071-fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a796/11529146/a4cdea84634a/10.1177_10406387241270071-fig7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a796/11529146/fee2a22af192/10.1177_10406387241270071-fig8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a796/11529146/54b79a0bb1fb/10.1177_10406387241270071-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a796/11529146/7e6c41b2662f/10.1177_10406387241270071-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a796/11529146/17fbe5f27445/10.1177_10406387241270071-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a796/11529146/4b3893ebaed3/10.1177_10406387241270071-fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a796/11529146/1a541da3bc64/10.1177_10406387241270071-fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a796/11529146/659716d68fc9/10.1177_10406387241270071-fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a796/11529146/a4cdea84634a/10.1177_10406387241270071-fig7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a796/11529146/fee2a22af192/10.1177_10406387241270071-fig8.jpg

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