Department of Neurology, Christian Hospital Unna, Unna, Germany.
Department of Neurology, University of Duisburg-Essen, Essen, Germany.
Cephalalgia. 2024 Aug;44(8):3331024241274343. doi: 10.1177/03331024241274343.
Few studies of migraine have evaluated migraine disability across multiple countries using the same methodology.
This cross-sectional, web-based survey was conducted in 2021-2022 in Canada, France, Germany, Japan, UK and USA. Respondents with migraine were identified based on modified International Classification of Headache Disorders, 3rd edition, criteria. Headache features (Migraine Symptom Severity Score (MSSS, range: 0-21), presence of allodynia (Allodynia Symptom Checklist, ASC-12)) and migraine burden (Patient Health Questionnaire-4 (PHQ-4), Migraine-Specific Quality of Life questionnaire version 2.1 (MSQ v2.1), Work Productivity and Activity Impairment (WPAI) questionnaire) were evaluated.
Among 14,492 respondents with migraine across countries, the mean ± SD MSSS was 15.4 ± 3.2 and 48.5% (7026/14,492) of respondents had allodynia based on ASC-12. Of all respondents living with migraine, 35.5% (5146/14,492) reported moderate to severe anxiety and/or depression symptoms. Mean ± SD MSQ v2.1 Role Function-Restrictive, Role Function-Preventive and Emotional Function domain scores were 60.7 ± 22.9, 71.5 ± 23.0 and 65.1 ± 27.2, respectively. The WPAI mean ± SD percentages of respondents who missed work or worked impaired as a result of migraine were 6.8 ± 18.1% and 41.0 ± 30.1%, respectively.
For every country surveyed, migraine was associated with high levels of symptom severity, with allodynia and with substantial burden.
很少有研究使用相同的方法评估多个国家的偏头痛致残情况。
本横断面、基于网络的研究于 2021 年至 2022 年在加拿大、法国、德国、日本、英国和美国进行。基于修改后的国际头痛疾病分类第 3 版标准，通过网络调查识别偏头痛患者。评估头痛特征（偏头痛症状严重程度评分（MSSS，范围：0-21）、痛觉过敏的存在（痛觉过敏症状检查表，ASC-12））和偏头痛负担（患者健康问卷-4（PHQ-4）、偏头痛特异性生活质量问卷 2.1 版（MSQ v2.1）、工作生产力和活动障碍（WPAI）问卷）。
在各国 14492 名偏头痛患者中，平均±标准差 MSSS 为 15.4±3.2，根据 ASC-12，48.5%（7026/14492）的患者存在痛觉过敏。在所有患有偏头痛的患者中，35.5%（5146/14492）报告存在中度至重度焦虑和/或抑郁症状。平均±标准差 MSQ v2.1 角色功能受限、角色功能预防和情感功能域得分分别为 60.7±22.9、71.5±23.0 和 65.1±27.2。由于偏头痛，WPAI 平均±标准差有 6.8±18.1%和 41.0±30.1%的患者缺勤或工作效率降低。
在所调查的每个国家，偏头痛均与高严重程度、痛觉过敏和大量负担有关。
