AbbVie, Irvine, CA, USA.
The Saul R. Korey Department of Neurology, Albert Einstein College of Medicine, Bronx, NY, USA.
Cephalalgia. 2023 Jun;43(6):3331024231180611. doi: 10.1177/03331024231180611.
The Chronic Migraine Epidemiology and Outcomes-International study provides insight into people with migraine in multiple countries.
This cross-sectional, observational, web-based cohort study was conducted in Canada, France, Germany, Japan, United Kingdom, and United States. An initial Screening Module survey solicited general healthcare information from a representative sample and identified participants with migraine based on modified criteria; those with migraine completed a detailed survey based on validated migraine-specific assessments.
Among 90,613 people who correctly completed the screening surveys, 76,121 respondents did not meet the criteria for migraine, while 14,492 did. Among respondents with migraine, mean age ranged from 40 to 42 years. The median number of monthly headache days ranged from 2.33 to 3.33 across countries, while the proportion of respondents with moderate-to-severe disability (measured by Migraine Disability Assessment) ranged from 30% (Japan) to 52% (Germany). The proportion of respondents with ≥15 monthly headache days ranged from 5.4% (France) to 9.5% (Japan). Fewer than half of respondents with migraine in each country reported having received a migraine diagnosis.
These results demonstrated high rates of migraine-related disability and underdiagnosis of migraine across six countries. This study will characterize country-level burden, treatment patterns, and geographical differences in care.
慢性偏头痛流行病学和结局-国际研究提供了多个国家偏头痛患者的相关信息。
这是一项在加拿大、法国、德国、日本、英国和美国进行的横断面、观察性、基于网络的队列研究。初始的筛选模块调查从代表性样本中收集一般医疗保健信息，并根据修改后的标准确定偏头痛患者；那些患有偏头痛的患者则根据经过验证的偏头痛特定评估完成详细调查。
在正确完成筛选调查的 90613 人中，有 76121 人不符合偏头痛标准，而有 14492 人符合标准。在偏头痛患者中，年龄中位数从各国的 40 岁到 42 岁不等。每月头痛天数的中位数从各国的 2.33 到 3.33 不等，而中度至重度残疾（用偏头痛残疾评估测量）的比例从 30%（日本）到 52%（德国）不等。每月头痛天数≥15 天的比例从 5.4%（法国）到 9.5%（日本）不等。在每个国家，不到一半的偏头痛患者报告曾被诊断出患有偏头痛。
这些结果表明，在六个国家中，偏头痛相关残疾和偏头痛漏诊的发生率都很高。本研究将描述各国的疾病负担、治疗模式和护理方面的地域差异。
