Zhu Xiao-Dan, Peng Yan-Jie, Chen Ying, Xue Mei, Zhang Ai-Juan, Peng Yu, Mei Rong, Tian Mei-Rong, Zhang Lin
Obstetrics Department, Shandong Provincial Maternal and Child Health Care Hospital Affiliated to Qingdao University, Jinan 250001, China.
Clinical Medical Research Center for Women and Children Diseases, Key Laboratory of Birth Regulation and Control Technology of National Health Commission of China Shandong Provincial Maternal and Child Health Care Hospital Affiliated to Qingdao University, Jinan 250001, China.
Vaccine X. 2024 Jul 26;20:100536. doi: 10.1016/j.jvacx.2024.100536. eCollection 2024 Oct.
This study aims to assess the risk of neonatal susceptibility to COVID-19 among pregnant women.
We conducted a retrospective cohort study involving 1089 pregnant women ≥28 weeks of gestational age, who were categorized into infected and uninfected groups. Data for all participants were collected through a comprehensive review of electronic medical records and follow-up phone calls. The primary outcome was neonatal infection with SARS-CoV-2, while secondary outcomes included delivery patterns and gestational age at delivery.
Maternal vaccination (OR 95%CI:0.63[0.46, 0.85]) and maternal infection with SARS-CoV-2 (OR 95%CI: 0.45[0.34, 0.60]) were found to be associated with a decreased risk of neonatal infection. The infected group exhibited a lower neonatal SARS-CoV-2 infection rate (25.93%) compared to the uninfected group (45.15%). Logistic regression analysis identified several risk factors associated with an increased risk of neonatal infection, including pregnancy BMI (OR 95%CI: 1.04[1.01, 1.08]), age at first pregnancy (OR 95%CI: 1.05[1.01, 1.10]), age at menarche (OR 95%CI: 1.13[1.02, 1.26]), and parturition (Yes vs. No) (OR 95%CI:1.4 [1.04,1.88]).
Maternal vaccination and perinatal infection with SARS-CoV-2 play a protective role in preventing neonatal SARS-CoV-2 infection.
本研究旨在评估孕妇中新生儿对新冠病毒易感性的风险。
我们进行了一项回顾性队列研究，纳入1089名孕周≥28周的孕妇，将其分为感染组和未感染组。通过全面查阅电子病历和随访电话收集所有参与者的数据。主要结局是新生儿感染严重急性呼吸综合征冠状病毒2（SARS-CoV-2），次要结局包括分娩方式和分娩时的孕周。
发现母体接种疫苗（比值比95%置信区间：0.63[0.46, 0.85]）和母体感染SARS-CoV-2（比值比95%置信区间：0.45[0.34, 0.60]）与新生儿感染风险降低相关。与未感染组（45.15%）相比，感染组的新生儿SARS-CoV-2感染率较低（25.93%）。逻辑回归分析确定了几个与新生儿感染风险增加相关的危险因素，包括妊娠体重指数（比值比95%置信区间：1.04[1.01, 1.08]）、初孕年龄（比值比95%置信区间：1.05[1.01, 1.10]）、月经初潮年龄（比值比95%置信区间：1.13[1.02, 1.26]）和分娩情况（是与否）（比值比95%置信区间：1.4[1.04, 1.88]）。
母体接种疫苗和围产期感染SARS-CoV-2在预防新生儿SARS-CoV-2感染中起保护作用。
