Usui N, Ogawa M, Inagaki J, Horikoshi N, Inoue K, Takano Y, Takagi K
Gan To Kagaku Ryoho. 1985 Jan;12(1):155-9.
A 36-year-old housewife in the U.S.A. was diagnosed as having gastric cancer with meningeal carcinomatosis and admitted to our hospital in September, 1982. She had severe headache, nausea, vomiting, diplopia and neck stiffness. She was treated by intrathecal chemotherapy using methotrexate, cytosine arabinoside and prednisolone, and by systemic chemotherapy using adriamycin and ftorafur, resulting in complete disappearance of cancer cells from the cerebrospinal fluid and partial response for the primary tumor. She lived for more than 1 year following the first symptoms of her disease and for 10 months following the initiation of chemotherapy. This case suggested the usefulness of employing an intrathecal chemotherapy using methotrexate and cytosine arabinoside with simultaneous systemic chemotherapy for meningeal carcinomatosis of gastric cancer.
一名36岁的美国家庭主妇被诊断为患有胃癌并伴有脑膜癌转移，于1982年9月住进我院。她有严重头痛、恶心、呕吐、复视和颈部强直。她接受了鞘内化疗，使用甲氨蝶呤、阿糖胞苷和泼尼松龙，以及全身化疗，使用阿霉素和喃氟啶，结果脑脊液中的癌细胞完全消失，原发肿瘤部分缓解。自疾病首次出现症状后她存活了1年多，化疗开始后存活了10个月。该病例提示，对于胃癌脑膜癌转移采用甲氨蝶呤和阿糖胞苷鞘内化疗并同时进行全身化疗是有用的。
