Ministrini Stefano, Wenzl Florian A, Lüscher Thomas F, Camici Giovanni G
Center for Molecular Cardiology, University of Zurich, Schlieren, Switzerland.
Royal Brompton and Harefield Hospitals, Imperial College and King's College, London, United Kingdom.
Cardiovasc Res. 2024 Aug 23. doi: 10.1093/cvr/cvae178.
Due to its peculiar structure and function, the cardiovascular system is particularly vulnerable to the detrimental effects of ageing. Current knowledge about the molecular mechanisms of ageing revealed the processes actively promoting ageing, e.g. progressive telomeres shortening, and the mechanisms opposing it, e.g. endogenous production of antioxidant substances. This knowledge can be used to measure biological age at a cellular and molecular level and to interfere with it by pharmacological or non-pharmacological interventions. Biological ageing is determined by the simultaneous occurrence of independent hallmarks, which encompass a wide range of biological processes, from genomic changes to systemic inflammation and dysbiosis. This narrative review will summarize the role of ageing hallmarks in the cardiovascular system, how they can be measured and what are the possible interventions to counteract their effects.
由于其独特的结构和功能，心血管系统特别容易受到衰老的有害影响。目前关于衰老分子机制的知识揭示了积极促进衰老的过程，如端粒逐渐缩短，以及与之相反的机制，如抗氧化物质的内源性产生。这些知识可用于在细胞和分子水平上测量生物学年龄，并通过药物或非药物干预来加以干预。生物学衰老由多种独立特征同时出现所决定，这些特征涵盖了从基因组变化到全身炎症和微生物群失调等广泛的生物学过程。这篇叙述性综述将总结衰老特征在心血管系统中的作用、如何对其进行测量以及有哪些可能的干预措施来抵消其影响。
