Wang Yu-Qing, Chen Li-Jia, Yang Rui-Lin, Lang Ming, Peng Jin-Bao
School of Pharmacy and Food Engineering, Wuyi University, Jiangmen, Guangdong, 529020, People's Republic of China.
Chemistry. 2024 Nov 12;30(63):e202402487. doi: 10.1002/chem.202402487. Epub 2024 Oct 16.
A base promoted oxidative [4+2] annulation of pyrrole-2-carbaldehyde derivatives with o-hydroxyphenyl propargylamines for the synthesis of highly substituted indolizines has been developed. Using DBN as base, a broad range of 5,6,7-trisubstituted indolizines have been prepared in good to excellent yields under mild conditions, and many useful functional groups can be tolerated.
已开发出一种碱促进的吡咯-2-甲醛衍生物与邻羟基苯基炔丙胺的氧化[4+2]环化反应，用于合成高度取代的中氮茚。以DBN作为碱，在温和条件下以良好至优异的产率制备了多种5,6,7-三取代的中氮茚，并且许多有用的官能团都能兼容。
