Inorganic Chemistry Department, C/Francisco Tomás y Valiente, 7. Universidad Autónoma de Madrid, 28049 Madrid, Spain.
IadChem, Institute for Advance Research in Chemistry, Universidad Autónoma de Madrid, 28049 Madrid, Spain.
Dalton Trans. 2024 Sep 18;53(36):14949-14960. doi: 10.1039/d4dt00967c.
Metals in medicine is a distinct and mature field of investigation. Its progress in recent times cannot be denied, as it provides opportunities to advance our knowledge of the properties, speciation, reactivity and biological effects of metals in a medicinal context. The development of novel Pt(II) compounds to combat cancer continues to make valuable contributions but it has not yet achieved a complete cure. The chemistry of this field is basic for drug design improvements and our analysis of the chemical procedures is a practical tool for achieving effective Pt(II) anticancer drugs. We present chemical approaches in a manner that can be used to strategically plot new synthetic routes choosing right pathways. Clarifying the chemical challenge will help the scientific community to be aware of the ease and/or difficulty of the procedure before and after further studies, such as speciation, reactivity and biological action which are also very arduous and costly. The work provides information to tackle many challenges in chemistry, combining the knowledge on the Pt(II) reagent preparation together with the reactivity of the biological units used in the Pt(II) drug design. We discuss and include the description of the chemical reactions, the importance of multiple steps and the right order of such reactions to achieve the final drugs, analyzing the coordination principles as well as the organic and organometallic basis. This thorough study of the routes helps to detect the simpler or more complicated reactivity and will serve to improve the synthesis performance with possible post-modifications.
金属医学是一个独特而成熟的研究领域。近年来，它的发展不容否认，因为它为我们在医学背景下提高对金属的性质、形态、反应性和生物效应的认识提供了机会。新型铂(II)化合物在抗癌方面的发展继续做出了有价值的贡献，但尚未实现完全治愈。该领域的化学对于药物设计的改进是基础，我们对化学过程的分析是实现有效铂(II)抗癌药物的实用工具。我们以可以战略性地规划新的合成路线的方式呈现化学方法，选择正确的途径。阐明化学挑战将帮助科学界在进一步研究（如形态、反应性和生物作用）之前和之后意识到该过程的难易程度，这些研究也非常艰巨和昂贵。这项工作提供了信息来应对化学领域的许多挑战，将铂(II)试剂制备的知识与铂(II)药物设计中使用的生物单元的反应性结合起来。我们讨论并包括了化学反应的描述、多步反应的重要性以及这些反应的正确顺序，以实现最终的药物，分析配位原理以及有机和有机金属基础。对这些路线的彻底研究有助于检测更简单或更复杂的反应性，并有助于提高可能的后期修饰后的合成性能。
