创伤后应激障碍与退伍军人队列中帕金森病发病风险的相关性研究。
Post-Traumatic Stress Disorder and Risk of Parkinson's Disease in a Veteran Cohort.
机构信息
Center of Innovation for Complex Chronic Healthcare (CINCCH), Edward Hines Jr. VA Hospital, Hines, IL, USA.
Parkinson School of Health Sciences and Public Health, Loyola University, Maywood, IL, USA.
出版信息
J Parkinsons Dis. 2024;14(6):1265-1269. doi: 10.3233/JPD-240098.
Post-traumatic stress disorder (PTSD) may be a risk factor for Parkinson's disease (PD). We examined the relation between PTSD and PD in a cohort of 158,122 Veterans who had any Veterans Health Administration (VHA) or Medicare health care utilization between 10/1/1999- 2/17/2021. Using a nested case-control design we matched 10 controls to each Veteran with PD by sex, race, and rank. In conditional logistic regression models adjusted for camp and smoking, a PTSD diagnosis was significantly associated with PD (OR = 1.35; p = 0.0002); odds were higher if PTSD was coded before PD (OR = 1.53, p < 0.0001). PTSD may be a risk factor for PD.
创伤后应激障碍（PTSD）可能是帕金森病（PD）的一个风险因素。我们在一个队列中检查了 PTSD 与 PD 之间的关系，该队列包括 158122 名退伍军人，他们在 1999 年 10 月 1 日至 2021 年 2 月 17 日期间在 Veterans Health Administration（VHA）或 Medicare 中有任何医疗保健利用。使用嵌套病例对照设计，我们通过性别、种族和职级为每位 PD 退伍军人匹配了 10 名对照。在调整了营地和吸烟因素的条件逻辑回归模型中，PTSD 诊断与 PD 显著相关（OR=1.35;p=0.0002）；如果 PTSD 在 PD 之前编码，可能性更高（OR=1.53，p<0.0001）。PTSD 可能是 PD 的一个风险因素。
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