Center of Innovation for Complex Chronic Healthcare (CINCCH), Edward Hines Jr. VA Hospital, Hines, IL, USA.
Parkinson School of Health Sciences and Public Health, Loyola University, Maywood, IL, USA.
J Parkinsons Dis. 2024;14(6):1265-1269. doi: 10.3233/JPD-240098.
Post-traumatic stress disorder (PTSD) may be a risk factor for Parkinson's disease (PD). We examined the relation between PTSD and PD in a cohort of 158,122 Veterans who had any Veterans Health Administration (VHA) or Medicare health care utilization between 10/1/1999- 2/17/2021. Using a nested case-control design we matched 10 controls to each Veteran with PD by sex, race, and rank. In conditional logistic regression models adjusted for camp and smoking, a PTSD diagnosis was significantly associated with PD (OR = 1.35; p = 0.0002); odds were higher if PTSD was coded before PD (OR = 1.53, p < 0.0001). PTSD may be a risk factor for PD.
创伤后应激障碍（PTSD）可能是帕金森病（PD）的一个风险因素。我们在一个队列中检查了 PTSD 与 PD 之间的关系，该队列包括 158122 名退伍军人，他们在 1999 年 10 月 1 日至 2021 年 2 月 17 日期间在 Veterans Health Administration（VHA）或 Medicare 中有任何医疗保健利用。使用嵌套病例对照设计，我们通过性别、种族和职级为每位 PD 退伍军人匹配了 10 名对照。在调整了营地和吸烟因素的条件逻辑回归模型中，PTSD 诊断与 PD 显著相关（OR=1.35;p=0.0002）；如果 PTSD 在 PD 之前编码，可能性更高（OR=1.53，p<0.0001）。PTSD 可能是 PD 的一个风险因素。
