Chen Yumei, Chen Yanbin
Technol Health Care. 2025;33(1):205-214. doi: 10.3233/THC-240821.
Although literature suggests that exercise can improve symptoms in Parkinson's Disease (PD) patients, research on the effects of aerobic exercise and resistance training (AE&RT) in early-stage PD remains limited. Understanding the synergistic effects of these exercise modalities can provide valuable insights for optimizing exercise interventions for PD patients, particularly in the early stages of the disease, where interventions may have the greatest impact on long-term functional outcomes.
This study aimed to investigate the effects of a combined AE&RT program on motor function, postural stability, and cognitive processing speed in early stage PD patients.
A total of 236 participants with early-stage PD were assigned to either the Aerobic Exercise Group (AE group) (n= 112) or the AE&RT Group (n= 124) inthis controlled randomized trial. The study employed a one-year supervised exercise program, with the AE Group participating in aerobic activities and the AE&RT Group engaging in combined AE&RT. Outcome measures included symptom improvement, motor function, postural stability, cognitive processing speed, peak oxygen consumption, quality of life evaluation, and the incidence of adverse events.
The AE&RT Group demonstrated greater improvements in tremor, muscle rigidity, gait instability, sleep problems, and hyposmia compared to the AE Group. Additionally, the combined exercise group exhibited better cognitive processing speed, as well as enhanced motor function and postural stability. Peak oxygen consumption was significantly higher in the AE&RT Group. However, the quality of life evaluation indicated a statistically higher quality of life in the AE Group. There was no significant difference in the incidence of adverse events between the two groups.
The findings suggest that the integration of AE&RT in early-stage PD patients leads to more comprehensive improvements in motor symptoms, cognitive function, postural stability, and cardiovascular fitness compared to aerobic exercise alone. These results have important implications for developing tailored exercise interventions to enhance the physical and cognitive well-being of individuals with early-stage PD.
尽管文献表明运动可以改善帕金森病（PD）患者的症状，但关于有氧运动和抗阻训练（AE&RT）对早期PD患者影响的研究仍然有限。了解这些运动方式的协同作用可为优化PD患者的运动干预提供有价值的见解，特别是在疾病的早期阶段，此时干预可能对长期功能结局产生最大影响。
本研究旨在调查联合AE&RT方案对早期PD患者运动功能、姿势稳定性和认知处理速度的影响。
在这项对照随机试验中，共有236名早期PD患者被分配到有氧运动组（AE组）（n = 112）或AE&RT组（n = 124）。该研究采用了为期一年的有监督运动方案，AE组参与有氧运动，AE&RT组进行联合AE&RT。结局指标包括症状改善、运动功能、姿势稳定性、认知处理速度、峰值耗氧量、生活质量评估和不良事件发生率。
与AE组相比，AE&RT组在震颤、肌肉僵硬、步态不稳、睡眠问题和嗅觉减退方面有更大改善。此外，联合运动组表现出更好的认知处理速度，以及增强的运动功能和姿势稳定性。AE&RT组的峰值耗氧量显著更高。然而，生活质量评估表明AE组的生活质量在统计学上更高。两组之间不良事件发生率没有显著差异。
研究结果表明，与单独的有氧运动相比，在早期PD患者中整合AE&RT可导致运动症状、认知功能、姿势稳定性和心血管健康方面更全面的改善。这些结果对于制定个性化运动干预措施以提高早期PD患者的身体和认知健康具有重要意义。
