Muğla Sıtkı Koçman University, Fethiye Faculty of Health Sciences, Department of Gerontology, Muğla, Türkiye.
Fırat University, Faculty of Health Sciences, Department of Physiotherapy and Rehabilitation, Elazığ, Türkiye.
J Neuroimmunol. 2024 Oct 15;395:578434. doi: 10.1016/j.jneuroim.2024.578434. Epub 2024 Aug 20.
The study aimed to evaluate the effect of high-intensity intermittent exercise (HIIE) on serum levels of MMP-9 and CHI3L1 in multiple sclerosis. Study group received HIIE twice a week for 12 weeks, while control group received no treatment. In intra-group comparison, study group showed a significant increase in MMP-9 and CHI3L1 levels, while control group showed no significant difference. In intergroup comparison, a significant difference was found only in CHI3L1 levels after treatment. The increase in MMP-9 and CH3L-1 concentrations in study group suggests that these biomarkers may play a role in regulating specific skeletal muscle adaptations due to HIIE.
本研究旨在评估高强度间歇训练（HIIE）对多发性硬化症患者血清中 MMP-9 和 CHI3L1 水平的影响。研究组接受每周 2 次、共 12 周的 HIIE，对照组则不接受任何治疗。组内比较显示，研究组的 MMP-9 和 CHI3L1 水平显著升高，而对照组则无显著差异。组间比较仅在治疗后 CHI3L1 水平上发现显著差异。研究组 MMP-9 和 CH3L-1 浓度的升高提示这些生物标志物可能在调节由于 HIIE 引起的特定骨骼肌适应性方面发挥作用。
