Neonatal Intensive Care Unit, Cleveland Clinic Children's Hospital, Cleveland, OH, USA; Faculty of Medicine, Aswan University, Aswan, Egypt.
Neonatal Intensive Care Unit, Cleveland Clinic Children's Hospital, Cleveland, OH, USA.
Early Hum Dev. 2024 Oct;197:106108. doi: 10.1016/j.earlhumdev.2024.106108. Epub 2024 Aug 22.
Necrotizing enterocolitis (NEC) is a major cause for morbidity and mortality among newborn infants. Chorioamnionitis is a perinatal complication that is associated with preterm delivery. Few reports have studied chorioamnionitis as a possible risk factor for NEC. Further investigation is needed to fully understand this association.
To examine the association of chorioamnionitis with NEC in newborn infants.
We used National Inpatient Sample (NIS) datasets produced by the federal Healthcare Cost and Utilization Project (HCUP). We identified infants born to mothers diagnosed with chorioamnionitis and infants born to mothers who did not have chorioamnionitis. The odds ratios (OR) to develop NEC in infants born to mothers affected by chorioamnionitis were calculated using chi square and Fisher Exact tests in the overall sample and in subgroups of different birthweight (BW) categories. The association was re-evaluated using logistic regression models to control for confounding variables.
The study identified 18,973,800 newborn infants admitted during the years 2016-2020. Among infants born to mothers with chorioamnionitis, NEC occurred in 0.9 % compared to 0.1 % in infants born to mothers without chorioamnionitis, (adjusted OR = 1.12, CI:1.02-1.15, p = 0.01). The prevalence of NEC in infants born to mothers with chorioamnionitis varied by the birth weight category, mainly for BW category 2500-4499 g (aOR = 1.61, CI:1.44-1.80, p < 0.001).
Maternal chorioamnionitis is associated with increased incidence of NEC, particularly in the BW category 2500-4499 g. Further studies are needed to examine the pathophysiological factors underlying this association.
坏死性小肠结肠炎（NEC）是新生儿发病率和死亡率的主要原因。绒毛膜羊膜炎是一种围产期并发症，与早产有关。很少有研究报告将绒毛膜羊膜炎作为 NEC 的一个可能危险因素进行研究。需要进一步研究以充分了解这种关联。
研究绒毛膜羊膜炎与新生儿 NEC 的关系。
我们使用联邦医疗保健成本和利用项目（HCUP）的国家住院患者样本（NIS）数据集。我们确定了母亲被诊断为绒毛膜羊膜炎的婴儿和母亲未患绒毛膜羊膜炎的婴儿。在总样本和不同出生体重（BW）类别亚组中，使用卡方和 Fisher 精确检验计算出母亲患有绒毛膜羊膜炎的婴儿患 NEC 的优势比（OR）。使用逻辑回归模型重新评估该关联，以控制混杂变量。
研究确定了 2016 年至 2020 年期间入住的 18973800 名新生儿。在母亲患有绒毛膜羊膜炎的婴儿中，NEC 的发生率为 0.9%，而母亲未患绒毛膜羊膜炎的婴儿中为 0.1%（调整后 OR=1.12，95%CI：1.02-1.15，p=0.01）。母亲患有绒毛膜羊膜炎的婴儿中 NEC 的患病率因出生体重类别而异，主要是 BW 类别 2500-4499g（aOR=1.61，95%CI：1.44-1.80，p<0.001）。
母亲绒毛膜羊膜炎与 NEC 发病率增加相关，尤其是在 BW 类别 2500-4499g 中。需要进一步研究以检查这种关联的病理生理因素。
