Underwood Mark A
Emeritus Professor of Pediatrics, University of California Davis, Sacramento, CA, USA.
J Perinatol. 2025 Mar 26. doi: 10.1038/s41372-025-02277-2.
The question of whether preterm infant formulas cause necrotizing enterocolitis (NEC) is the subject of multiple lawsuits and has daily relevance in the care of preterm infants. Research supporting the hypothesis that toxic components in infant formula cause NEC is limited to preclinical data while data from human infants are lacking. Human milk should be the first choice for most preterm infants, however, preterm infant formula is at times a critical alternative. It is the absence of human milk that increases NEC risk rather than toxic components in preterm infant formula.
早产婴儿配方奶粉是否会导致坏死性小肠结肠炎（NEC）这一问题是多起诉讼的主题，并且在早产婴儿护理中每天都具有现实意义。支持婴儿配方奶粉中的有毒成分会导致坏死性小肠结肠炎这一假说的研究仅限于临床前数据，而缺乏来自人类婴儿的数据。对于大多数早产婴儿来说，母乳应该是首选，然而，早产婴儿配方奶粉有时是关键的替代品。是缺乏母乳增加了坏死性小肠结肠炎的风险，而非早产婴儿配方奶粉中的有毒成分。
