Chen Jun, Yao Yongxue, Pei Xinyu, Qu Maoting, Zhang Jiahao, Hu Wen, Zhang Yuanyuan, Wu Wen, Pei Shuchen
College of Chemistry and Chemical Engineering, Chongqing University of Science and Technology, Chongqing 401331, PR China.
Chongqing Key Laboratory of High Active Traditional Chinese Drug Delivery System, Chongqing Engineering Research Center of Pharmaceutical Sciences, Chongqing Medical and Pharmaceutical College, Chongqing 404120, PR China.
Spectrochim Acta A Mol Biomol Spectrosc. 2025 Jan 5;324:125009. doi: 10.1016/j.saa.2024.125009. Epub 2024 Aug 22.
Fluoride ions (F) are one of the essential trace elements for the human body and are widely existed in nature. In this study, we present a novel fluorescent probe (YF-SZ-F) designed and synthesized for the specific detection of F. The probe exhibits high sensitivity, excellent selectivity, and low cytotoxicity, making it a promising tool for biomedical applications. Imaging experiments conducted on zebrafish and Arabidopsis roots demonstrate the probe's remarkable cellular permeability and biocompatibility, laying a solid foundation for its potential biomedical utility. Furthermore, the probe holds potential for practical applications in environmental monitoring and public health through its capability to detect fluoride ions in water samples and via mobile phone software. This multifaceted functionality underscores the broad applicability and significance of the fluorescent probe, not only in scientific research but also in real-world scenarios, contributing to the development of more convenient and precise methods for fluoride detection.
氟离子（F）是人体必需的微量元素之一，广泛存在于自然界中。在本研究中，我们展示了一种设计并合成的用于特异性检测氟离子的新型荧光探针（YF-SZ-F）。该探针具有高灵敏度、优异的选择性和低细胞毒性，使其成为生物医学应用中有前景的工具。在斑马鱼和拟南芥根上进行的成像实验证明了该探针具有显著的细胞渗透性和生物相容性，为其潜在的生物医学应用奠定了坚实基础。此外，该探针通过其检测水样中氟离子的能力以及借助手机软件，在环境监测和公共卫生方面具有实际应用潜力。这种多方面的功能强调了荧光探针的广泛适用性和重要性，不仅在科学研究中，而且在实际场景中，有助于开发更便捷、精确的氟离子检测方法。
