两个同时产 MCR-9 和 KPC-2 的肺炎克雷伯菌分离株中由 IS903B 介导的染色体与质粒融合事件。
Fusion event mediated by IS903B between chromosome and plasmid in two MCR-9- and KPC-2-co-producing Klebsiella pneumoniae isolates.
机构信息
Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Department of Neurosurgery, Shaoxing People's Hospital (Shaoxing Hospital, Zhejiang University School of Medicine), Shaoxing, China.
出版信息
Drug Resist Updat. 2024 Nov;77:101139. doi: 10.1016/j.drup.2024.101139. Epub 2024 Aug 17.
Herein, we first isolated two MCR-9- and KPC-2-co-producing K. pneumoniae isolates. Notably, we observed a fusion event between the chromosome and plasmid, mediated by IS903B, in these two strains. This cointegration of chromosomes and plasmids introduces a new mode of transmission for antimicrobial resistance genes.
在此，我们首次分离到两株同时携带 MCR-9 和 KPC-2 的肺炎克雷伯菌。值得注意的是，我们观察到这两株菌中存在由 IS903B 介导的染色体与质粒之间的融合事件。这种染色体与质粒的共整合为抗菌药物耐药基因的传播引入了一种新的方式。
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