Joint International Research Laboratory of Environment and Health, Ministry of Education, Guangdong Provincial Engineering Technology Research Center of Environmental Pollution and Health Risk Assessment, Department of Occupational and Environmental Health, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China.
Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Department of Toxicology, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China.
J Hazard Mater. 2024 Oct 5;478:135577. doi: 10.1016/j.jhazmat.2024.135577. Epub 2024 Aug 18.
Evidence on the link of long-term exposure to ozone (O) with childhood asthma, rhinitis, conjunctivitis and eczema is inconclusive. We did a population-based cross-sectional survey, including 177,888 children from 173 primary and middle schools in 14 Chinese cities. A satellite-based spatiotemporal model was employed to assess four-year average O exposure at both residential and school locations. Information on asthma, allergic rhinitis, eczema and conjunctivitis was collected by a standard questionnaire developed by the American Thoracic Society. We used generalized non-linear and linear mixed models to test the associations. We observed linear exposure-response associations between O and all outcomes. The odds ratios of doctor-diagnosed asthma, rhinitis, eczema, and conjunctivitis associated with per interquartile increment in home-school O concentration were 1.31 (95 % confidence interval [CI]: 1.28, 1.34), 1.25 (95 %CI: 1.23, 1.28), 1.19 (95 %CI: 1.16, 1.21), and 1.28 (95 %CI: 1.21, 1.34), respectively. Similar associations were observed for asthma-related outcomes including current asthma, wheeze, current wheeze, persistent phlegm, and persistent cough. Moreover, stronger associations were observed among children who were aged > 12 years, physically inactive, and exposed to higher temperature. In conclusion, long-term O exposure was associated with higher risks of asthma, allergic rhinitis, conjunctivitis and eczema in children.
长期暴露于臭氧（O）与儿童哮喘、鼻炎、结膜炎和湿疹之间的关联证据尚无定论。我们进行了一项基于人群的横断面调查，纳入了来自中国 14 个城市的 173 所中小学的 177888 名儿童。采用基于卫星的时空模型评估住宅和学校地点的四年平均 O 暴露水平。通过美国胸科学会制定的标准问卷收集哮喘、过敏性鼻炎、湿疹和结膜炎的信息。我们使用广义非线性和线性混合模型来检验关联。我们观察到 O 与所有结局之间存在线性暴露反应关联。与家庭-学校 O 浓度每增加一个四分位间距相关的哮喘、鼻炎、湿疹和结膜炎的医生诊断比值比分别为 1.31（95%置信区间[CI]：1.28，1.34）、1.25（95%CI：1.23，1.28）、1.19（95%CI：1.16，1.21）和 1.28（95%CI：1.21，1.34）。对于哮喘相关结局，包括当前哮喘、喘息、当前喘息、持续咳痰和持续咳嗽，也观察到类似的关联。此外，在年龄>12 岁、身体不活跃和暴露于较高温度的儿童中，观察到更强的关联。总之，长期 O 暴露与儿童哮喘、过敏性鼻炎、结膜炎和湿疹的风险增加相关。
