Cotton D J, Graham B L, Mink J T, Habbick B F
Chest. 1985 Feb;87(2):217-22. doi: 10.1378/chest.87.2.217.
The single breath diffusing capacity of the lung for carbon monoxide (Dsb) was measured using three equations to describe CO uptake separately during inhalation, breath holding, and exhalation in 24 patients with cystic fibrosis and 30 control subjects with similar age and height distributions. Using the control group, we developed two prediction equations for Dsb: one based on height, age, and sex; and another based on alveolar lung volume (VA) to the 2/3 power. We also developed a prediction for Dsb/VA (Kco) based on height. The Dsb as percent predicted (% pred) using either prediction equation decreased with increasing age and height as well as with decreasing % pred maximal midexpiratory flow rate (FEF25-75) in cystic fibrosis patients but not in controls. The Kco (% pred) also decreased in cystic fibrosis with increasing age and decreasing percent pred FEF25-75. We conclude that in patients with cystic fibrosis, Dsb decreases with variables that relate to increasing disease severity (age, height, and increasing airflow obstruction).
采用三个方程分别描述24例囊性纤维化患者和30例年龄及身高分布相似的对照受试者在吸气、屏气和呼气过程中一氧化碳的摄取情况，以此来测量肺一氧化碳单次呼吸弥散量（Dsb）。利用对照组，我们得出了两个Dsb预测方程：一个基于身高、年龄和性别；另一个基于肺泡肺容积（VA）的2/3次幂。我们还得出了基于身高的Dsb/VA（Kco）预测方程。在囊性纤维化患者中，使用任一预测方程得出的预测Dsb百分比（%pred）随年龄和身高增加以及最大呼气中期流速（FEF25 - 75）的预测百分比降低而降低，但在对照受试者中并非如此。囊性纤维化患者的Kco（%pred）也随年龄增加和FEF25 - 75预测百分比降低而降低。我们得出结论，在囊性纤维化患者中，Dsb随与疾病严重程度增加相关的变量（年龄、身高和气流阻塞增加）而降低。
