School of Pharmacy, Jiangxi University of Traditional Chinese Medicine, Nanchang, Jiangxi, China.
Department of Cardiovascular Medicine, Jiangxi Provincial People's Hospital, The First Affiliated Hospital of Nanchang Medical College, Nanchang, Jiangxi, China.
Sci Rep. 2024 Aug 23;14(1):19629. doi: 10.1038/s41598-024-70666-2.
Glycosylated haemoglobin index (HGI) has been shown to correlate with the prognosis of metabolic diseases, but the relationship with mortality remains unclear. This study included 18,285 US adults who participated in the National Health and Nutrition Examination Survey (NHANES) between 1999 and 2018. During the median follow-up period of 115 months, a total of 2572 all-cause deaths and 671 cardiovascular disease (CVD) deaths occurred. The restricted cubic spline revealed a U-shaped correlation between HGI and all-cause and CVD mortality. After adjusting for all covariates, the optimal inflection point values in all-cause and CVD deaths were 0.17 and 0.02, respectively. In the left side of the inflection point, the risk of all-cause mortality and CVD mortality decreased by approximately 24% (HR 0.76, 95% CI 0.69, 0.84) and 25% (HR 0.75, 95% CI 0.60, 0.96) with the increase in HGI. Conversely, in the right of the inflection point, an increase of 1 unit in the HGI was linked with a 17% (HR 1.17, 95% CI 1.07, 1.27) and 31% (HR 1.31, 95% CI 1.15, 1.49) increase in all-cause and CVD mortality. Our study showed that HGI is an important tool for predicting the risk of all-cause mortality and CVD death in US adults and there is a U-shaped relationship between HGI and mortality.
糖化血红蛋白指数 (HGI) 已被证明与代谢性疾病的预后相关，但与死亡率的关系尚不清楚。本研究纳入了 1999 年至 2018 年期间参加美国国家健康和营养调查 (NHANES) 的 18285 名美国成年人。在中位数为 115 个月的随访期间，共有 2572 例全因死亡和 671 例心血管疾病 (CVD) 死亡。限制三次样条显示 HGI 与全因和 CVD 死亡率之间呈 U 形相关。在调整了所有协变量后，全因和 CVD 死亡的最佳拐点值分别为 0.17 和 0.02。在拐点的左侧，全因死亡率和 CVD 死亡率的风险分别降低了约 24%（HR 0.76，95%CI 0.69，0.84）和 25%（HR 0.75，95%CI 0.60，0.96），HGI 增加。相反，在拐点的右侧，HGI 增加 1 个单位与全因死亡率和 CVD 死亡率分别增加 17%（HR 1.17，95%CI 1.07，1.27）和 31%（HR 1.31，95%CI 1.15，1.49）相关。我们的研究表明，HGI 是预测美国成年人全因死亡率和 CVD 死亡风险的重要工具，HGI 与死亡率之间呈 U 形关系。
