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An age-progressive platelet differentiation path from hematopoietic stem cells causes exacerbated thrombosis.从造血干细胞到血小板的年龄进展性分化途径可导致血栓形成加剧。
Cell. 2024 Jun 6;187(12):3090-3107.e21. doi: 10.1016/j.cell.2024.04.018. Epub 2024 May 14.
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Depleting myeloid-biased haematopoietic stem cells rejuvenates aged immunity.耗竭偏向髓系的造血干细胞可恢复衰老的免疫。
Nature. 2024 Apr;628(8006):162-170. doi: 10.1038/s41586-024-07238-x. Epub 2024 Mar 27.
4
Platelets and Their Role in Hemostasis and Thrombosis-From Physiology to Pathophysiology and Therapeutic Implications.血小板及其在止血和血栓形成中的作用——从生理学到病理生理学及治疗意义。
Int J Mol Sci. 2022 Oct 23;23(21):12772. doi: 10.3390/ijms232112772.
5
Fate mapping of hematopoietic stem cells reveals two pathways of native thrombopoiesis.造血干细胞的命运图谱揭示了两种内源性血小板生成途径。
Nat Commun. 2022 Aug 3;13(1):4504. doi: 10.1038/s41467-022-31914-z.
6
Challenges and Advances in Managing Thrombocytopenic Cancer Patients.血小板减少症癌症患者管理中的挑战与进展
J Clin Med. 2021 Mar 11;10(6):1169. doi: 10.3390/jcm10061169.
7
Modulators of platelet function in aging.衰老过程中血小板功能的调节剂。
Platelets. 2020 May 18;31(4):474-482. doi: 10.1080/09537104.2019.1665641. Epub 2019 Sep 16.
8
From haematopoietic stem cells to complex differentiation landscapes.从造血干细胞到复杂的分化景观。
Nature. 2018 Jan 24;553(7689):418-426. doi: 10.1038/nature25022.
9
Clonal analysis of lineage fate in native haematopoiesis.对天然造血中谱系命运的克隆分析。
Nature. 2018 Jan 11;553(7687):212-216. doi: 10.1038/nature25168. Epub 2018 Jan 3.
10
Hierarchically related lineage-restricted fates of multipotent haematopoietic stem cells.多能造血干细胞的层次相关谱系限制命运。
Nature. 2018 Feb 1;554(7690):106-111. doi: 10.1038/nature25455. Epub 2018 Jan 3.

Preservation of a youthful path to evergreen platelets?

作者信息

Jacobsen Sten Eirik W

机构信息

Department of Cell and Molecular Biology and Department of Medicine Huddinge, Center for Hematology and Regenerative Medicine, Karolinska Institutet and Karolinska University Hospital Huddinge, Stockholm, Sweden.

Haematopoietic Stem Cell Biology Laboratory and MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.

出版信息

Cell Res. 2025 Feb;35(2):93-94. doi: 10.1038/s41422-024-01015-1.

DOI:10.1038/s41422-024-01015-1
PMID:39179738
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11770061/
Abstract
摘要