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空气污染物颗粒物(PM,PM)、二氧化硫(SO)和臭氧(O)对认知健康的影响。

Effect of air pollutants particulate matter (PM, PM), sulfur dioxide (SO) and ozone (O) on cognitive health.

机构信息

Department of Physiology, College of Medicine, King Saud University, Riyadh, Saudi Arabia.

College of Medicine, King Saud University, Riyadh, Saudi Arabia.

出版信息

Sci Rep. 2024 Aug 23;14(1):19616. doi: 10.1038/s41598-024-70646-6.

Abstract

Impaired cognitive health is the leading cause of various disabilities and disorders. Air pollution has been dramatically increasing over the last few decades and has been identified as a potential risk factor for impaired cognitive health. This study investigates the effect of air pollutants, particulate matter (PM, PM), sulfur dioxide (SO), and ground-level ozone, on global cognitive health. The data on environmental pollutants and cognitive health were recorded from PubMed, Web of Science, Scopus, and Google Scholar. Initially, 790 articles were identified after screening for duplicates and applying the inclusion and exclusion criteria, 21 studies were included, and data was synthesized to get a pooled result. The overall results revealed that increased exposure to PM was positively and significantly associated with cognitive decline (OR 1.49; 95% CI 1.11, 1.99; p = 0.01). The risk of cognitive impairment due to PM (OR 1.30; 95% CI 1.00-1.70, p = 0.05), and SO (OR 1.39; 95% CI 1.27-1.51; p < 0.01) exposure were also significantly heightened. The study findings show that overall exposure to particulate matter PM PM and SO was associated with an increased risk of a decrease in global cognitive functions. The findings suggest that reducing levels of air pollutants could be a strategic approach to mitigate cognitive health risks in populations worldwide.

摘要

认知健康受损是各种残疾和障碍的主要原因。在过去几十年中,空气污染急剧增加,并已被确定为认知健康受损的潜在危险因素。本研究调查了空气污染物、颗粒物(PM,PM)、二氧化硫(SO)和地面臭氧对全球认知健康的影响。环境污染物和认知健康的数据来自 PubMed、Web of Science、Scopus 和 Google Scholar。最初,在筛选重复项并应用纳入和排除标准后,确定了 790 篇文章,纳入了 21 项研究,并综合数据得出了汇总结果。总体结果表明,PM 暴露增加与认知能力下降呈正相关且显著相关(OR 1.49;95%CI 1.11, 1.99;p=0.01)。由于 PM(OR 1.30;95%CI 1.00-1.70,p=0.05)和 SO(OR 1.39;95%CI 1.27-1.51;p<0.01)暴露而导致认知障碍的风险也显著增加。研究结果表明,总体暴露于颗粒物 PM 和 SO 与全球认知功能下降的风险增加有关。研究结果表明,降低空气污染物水平可能是减轻全球人口认知健康风险的一种策略。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cab7/11343771/ba1ed6151d54/41598_2024_70646_Fig1_HTML.jpg

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