腹膜和肾脏 DKK3 清除率在腹膜透析中的作用。

Peritoneal and renal DKK3 clearance in peritoneal dialysis.

机构信息

Nephrology Section, Medical Clinic 1, University Hospital Bonn, Rheinische Friedrich- Wilhelms Universität Bonn, Venusberg Campus 1, D-53127, Bonn, Germany.

Kuratorium for Dialysis, KfH Renal Center, Bonn, Germany.

出版信息

BMC Nephrol. 2024 Aug 23;25(1):268. doi: 10.1186/s12882-024-03715-7.

DOI:10.1186/s12882-024-03715-7

PMID:39179976

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11342714/

Abstract

BACKGROUND

Urinary Dickkopf 3 (DKK3) excretion is a recently established biomarker of renal functional development. Its excretion into the peritoneal cavity has not been reported. We here studied DKK3 in peritoneal dialysis.

METHODS

DKK3 was assessed in serum, urine and dialysate in a prevalent adult peritoneal dialysis cohort and its concentration analyzed in relation to creatinine and clinical characteristics.

RESULTS

Highest DKK3 concentrations were found in serum, followed by urine. Dialysate concentrations were significantly lower. Dialysate DKK3 correlated with both other compartments. Serum, dialysate and urine values were stable during three months of follow-up. Continuous ambulatory dialysis (CAPD) but not cycler-assisted peritoneal dialysis (CCPD) volume-dependently increased peritoneal DKK3 in relation to creatinine. RAAS blockade significantly decreased urinary, but not serum or peritoneal DKK3.

CONCLUSION

Our data provide a detailed characterization of DKK3 in peritoneal dialysis. They support the notion that the RAAS system is essential for renal DKK3 handling.

摘要

背景

尿 Dickkopf 3（DKK3）排泄是新近建立的肾功能发育生物标志物。其在腹腔内的排泄尚未见报道。我们在此研究了腹膜透析中的 DKK3。

方法

在一个现患的成年腹膜透析队列中评估了血清、尿液和透析液中的 DKK3，并分析了其浓度与肌酐和临床特征的关系。

结果

血清中 DKK3 浓度最高，其次是尿液。透析液浓度明显较低。透析液 DKK3 与其他两个隔室均相关。在三个月的随访期间，血清、透析液和尿液值均稳定。连续不卧床腹膜透析（CAPD）而非循环辅助腹膜透析（CCPD）与肌酐相关的腹膜 DKK3 呈容积依赖性增加。RAAS 阻断显著降低了尿 DKK3，但不降低血清或腹膜 DKK3。