• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

RARB 与 MSI 相关，影响胃癌的进展和预后。

RARB associated with MSI, affects progression and prognosis of gastric cancer.

机构信息

Graduate School, Zhejiang Chinese Medicine University, Hangzhou, Zhejiang, China.

Department of Gastrointestinal Surgery, The Second Affiliated Hospital of Zhejiang Chinese Medical University Hangzhou, Hangzhou, Zhejiang, China.

出版信息

BMC Gastroenterol. 2024 Aug 23;24(1):285. doi: 10.1186/s12876-024-03339-z.

DOI:10.1186/s12876-024-03339-z
PMID:39179979
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11342619/
Abstract

Microsatellite instability (MSI) has been widely acknowledged as an important factor regulating tumor intrinsic biological behavior and affecting the survival of gastric cancer patients. Here, we firstly identified the RARB as a gene associated with MSI gastric cancer. RARB was downregulated in human gastric cancer tissues compared to paired paracancerous tissues, Knockdown of RARB accelerated the proliferation, invasion and migration of cancer cells in vitro. Mechanismly, RARB knockdown promoted epithelial-mesenchymal transition (EMT) process of gastric cancer. However, RARB patients exhibited better survival compared to RARB patients. Further study revealed that RARB expression was inversely correlated with MSI status and immune infiltrates in vivo. Thus, RARB may be a potential target for the treatment of gastric cancer.

摘要

微卫星不稳定性（MSI）已被广泛认为是调节肿瘤内在生物学行为和影响胃癌患者生存的重要因素。在这里，我们首次鉴定出 RARB 是与 MSI 胃癌相关的基因。与配对的癌旁组织相比，RARB 在人类胃癌组织中下调，RARB 敲低可加速体外癌细胞的增殖、侵袭和迁移。机制上，RARB 敲低促进了胃癌的上皮-间充质转化（EMT）过程。然而，RARB 患者的生存情况优于 RARB 患者。进一步的研究表明，RARB 的表达与体内 MSI 状态和免疫浸润呈负相关。因此，RARB 可能是胃癌治疗的潜在靶点。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d758/11342619/5073301745c8/12876_2024_3339_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d758/11342619/03b73b77bb3c/12876_2024_3339_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d758/11342619/4a6a401e8d4e/12876_2024_3339_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d758/11342619/707543c535f3/12876_2024_3339_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d758/11342619/69b0c571fde8/12876_2024_3339_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d758/11342619/a4b3205e3a62/12876_2024_3339_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d758/11342619/5073301745c8/12876_2024_3339_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d758/11342619/03b73b77bb3c/12876_2024_3339_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d758/11342619/4a6a401e8d4e/12876_2024_3339_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d758/11342619/707543c535f3/12876_2024_3339_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d758/11342619/69b0c571fde8/12876_2024_3339_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d758/11342619/a4b3205e3a62/12876_2024_3339_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d758/11342619/5073301745c8/12876_2024_3339_Fig6_HTML.jpg

相似文献

1
RARB associated with MSI, affects progression and prognosis of gastric cancer.RARB 与 MSI 相关，影响胃癌的进展和预后。
BMC Gastroenterol. 2024 Aug 23;24(1):285. doi: 10.1186/s12876-024-03339-z.
2
MiR-675 is frequently overexpressed in gastric cancer and enhances cell proliferation and invasion via targeting a potent anti-tumor gene PITX1.miR-675 在胃癌中经常过表达，通过靶向一种有效的抗肿瘤基因 PITX1 促进细胞增殖和侵袭。
Cell Signal. 2019 Oct;62:109352. doi: 10.1016/j.cellsig.2019.109352. Epub 2019 Jun 28.
3
Overexpression of FNDC1 Relates to Poor Prognosis and Its Knockdown Impairs Cell Invasion and Migration in Gastric Cancer.FNDC1 过表达与不良预后相关，其敲低可抑制胃癌细胞侵袭和迁移。
Technol Cancer Res Treat. 2019 Jan 1;18:1533033819869928. doi: 10.1177/1533033819869928.
4
Long non-coding RNA ZEB2-AS1 expression is associated with disease progression and predicts outcome in gastric cancer patients.长链非编码RNA ZEB2-AS1的表达与疾病进展相关，并可预测胃癌患者的预后。
J BUON. 2019 Mar-Apr;24(2):663-671.
5
Alpha B-crystallin promotes the invasion and metastasis of gastric cancer via NF-κB-induced epithelial-mesenchymal transition.αB-晶状体蛋白通过 NF-κB 诱导的上皮-间充质转化促进胃癌的侵袭和转移。
J Cell Mol Med. 2018 Jun;22(6):3215-3222. doi: 10.1111/jcmm.13602. Epub 2018 Mar 22.
6
CXCR6 predicts poor prognosis in gastric cancer and promotes tumor metastasis through epithelial-mesenchymal transition.CXCR6预示胃癌预后不良，并通过上皮-间质转化促进肿瘤转移。
Oncol Rep. 2017 Jun;37(6):3279-3286. doi: 10.3892/or.2017.5598. Epub 2017 Apr 25.
7
ZEB2 promotes the metastasis of gastric cancer and modulates epithelial mesenchymal transition of gastric cancer cells.ZEB2 促进胃癌的转移，并调节胃癌细胞的上皮间质转化。
Dig Dis Sci. 2012 May;57(5):1253-60. doi: 10.1007/s10620-012-2042-6. Epub 2012 Feb 16.
8
[CircPCSK5 is highly expressed in gastric cancer and promotes cancer cell proliferation, invasion and epithelial-mesenchymal transition].环状前蛋白转化酶枯草溶菌素5在胃癌中高表达并促进癌细胞增殖、侵袭及上皮-间质转化
Nan Fang Yi Ke Da Xue Xue Bao. 2022 Oct 20;42(10):1440-1451. doi: 10.12122/j.issn.1673-4254.2022.10.02.
9
High intratumoral expression of eIF4A1 promotes epithelial-to-mesenchymal transition and predicts unfavorable prognosis in gastric cancer.肿瘤内高水平的 eIF4A1 表达促进上皮-间充质转化，并预测胃癌的不良预后。
Acta Biochim Biophys Sin (Shanghai). 2020 Mar 18;52(3):310-319. doi: 10.1093/abbs/gmz168.
10
The effect and clinical significance of FN1 expression on biological functions of gastric cancer cells.FN1 表达对胃癌细胞生物学功能的影响及其临床意义。
Cell Mol Biol (Noisy-le-grand). 2020 Jul 31;66(5):191-198.

引用本文的文献

1
TMT-based quantitative proteomic analysis of IBDV-infected CEF cells reveals a favorable role of chicken IRF10 in IBDV replication via suppressing type-I interferon expression.基于TMT的传染性法氏囊病病毒感染的鸡胚成纤维细胞定量蛋白质组学分析揭示了鸡干扰素调节因子10通过抑制I型干扰素表达在传染性法氏囊病病毒复制中发挥有利作用。
Poult Sci. 2024 Dec;103(12):104421. doi: 10.1016/j.psj.2024.104421. Epub 2024 Oct 13.

本文引用的文献

1
Retinoic acid receptor β modulates mechanosensing and invasion in pancreatic cancer cells via myosin light chain 2.维甲酸受体β通过肌球蛋白轻链2调节胰腺癌细胞的机械传感和侵袭。
Oncogenesis. 2023 May 2;12(1):23. doi: 10.1038/s41389-023-00467-1.
2
Epigenetic regulation of RARB overcomes the radio-resistance of colorectal carcinoma cells via cancer stem cells.通过癌症干细胞，RARB 的表观遗传调控克服了结直肠癌细胞的放射抵抗性。
J Radiat Res. 2023 Jan 20;64(1):11-23. doi: 10.1093/jrr/rrac060.
3
Prognostic impact of microsatellite instability in gastric cancer.
微卫星不稳定性在胃癌中的预后影响
Contemp Oncol (Pozn). 2021;25(1):68-71. doi: 10.5114/wo.2021.104939. Epub 2021 Feb 23.
4
Microsatellite instability in Gastric Cancer: Between lights and shadows.胃癌中的微卫星不稳定性：在光明与阴影之间。
Cancer Treat Rev. 2021 Apr;95:102175. doi: 10.1016/j.ctrv.2021.102175. Epub 2021 Mar 1.
5
Gastric cancer.胃癌。
Lancet. 2020 Aug 29;396(10251):635-648. doi: 10.1016/S0140-6736(20)31288-5.
6
Heterogeneity of MSI-H gastric cancer identifies a subtype with worse survival.MSI-H 型胃癌的异质性确定了一种生存状况更差的亚型。
J Med Genet. 2021 Jan;58(1):12-19. doi: 10.1136/jmedgenet-2019-106609. Epub 2020 Mar 13.
7
Prognostic and Predictive Value of Microsatellite Instability, Inflammatory Reaction and PD-L1 in Gastric Cancer Patients Treated with Either Adjuvant 5-FU/LV or Sequential FOLFIRI Followed by Cisplatin and Docetaxel: A Translational Analysis from the ITACA-S Trial.微卫星不稳定性、炎症反应和 PD-L1 在接受辅助 5-FU/LV 或序贯 FOLFIRI 后顺铂和多西紫杉醇治疗的胃癌患者中的预后和预测价值：来自 ITACA-S 试验的转化分析。
Oncologist. 2020 Mar;25(3):e460-e468. doi: 10.1634/theoncologist.2019-0471. Epub 2019 Nov 25.
8
Retinoid X receptor agonist LG100268 modulates the immune microenvironment in preclinical breast cancer models.维甲酸X受体激动剂LG100268在临床前乳腺癌模型中调节免疫微环境。
NPJ Breast Cancer. 2019 Nov 1;5:39. doi: 10.1038/s41523-019-0135-5. eCollection 2019.
9
A Comprehensive PDX Gastric Cancer Collection Captures Cancer Cell-Intrinsic Transcriptional MSI Traits.全面的 PDX 胃癌集合捕获了肿瘤细胞内在的转录 MSI 特征。
Cancer Res. 2019 Nov 15;79(22):5884-5896. doi: 10.1158/0008-5472.CAN-19-1166. Epub 2019 Oct 4.
10
Retinoic acid receptor beta promoter methylation and risk of cervical cancer.维甲酸受体β启动子甲基化与宫颈癌风险
World J Virol. 2018 Feb 12;7(1):1-9. doi: 10.5501/wjv.v7.i1.1.