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口腔鳞状细胞癌患者中SOX2和SOX9的表达分析。

Expression analysis of SOX2 and SOX9 in patients with oral squamous cell carcinoma.

作者信息

Steen Sonja, Horn Dominik, Flechtenmacher Christa, Hoffmann Jürgen, Freier Kolja, Ristow Oliver, Hess Jochen, Moratin Julius

机构信息

Department of Oral and Cranio-Maxillofacial Surgery, University of Heidelberg, Heidelberg, Germany.

Department of Oral and Cranio-Maxillofacial Surgery, Saarland University Hospital, Homburg, Germany.

出版信息

Head Neck. 2025 Feb;47(2):437-451. doi: 10.1002/hed.27925. Epub 2024 Aug 23.

DOI:10.1002/hed.27925
PMID:39180200
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11717967/
Abstract

BACKGROUND

Lately SOX2 and SOX9, transcription factors associated with stemness-like phenotypes of cancer cells, have been linked to tumor growth, metastasis, and resistance to therapy.

METHODS

This study aimed on evaluating the expression of SOX2 and SOX9 in a large cohort of patients with OSCC including primary and recurrent tumors and corresponding lymph node metastases. Semiautomatic digital pathology scoring was used to determine protein expression and survival analysis was performed to evaluate its prognostic significance.

RESULTS

We found a significant downregulation of SOX9 from primary disease to lymph node metastases (p < 0.001). SOX9 expression and the subgroup SOX2SOX9 were significantly correlated with worse overall survival (p < 0.05). Additionally, SOX2SOX9 expression pattern was confirmed as independent prognosticator for overall survival.

CONCLUSIONS

These results indicate the relevant role of SOX2 and SOX9 in patients with OSCC and show the clinical relevance for further investigation on the molecular mechanisms underlying SOX-related gene expression.

摘要

背景

最近，与癌细胞干性样表型相关的转录因子SOX2和SOX9已被证明与肿瘤生长、转移及治疗耐药性有关。

方法

本研究旨在评估一大群口腔鳞状细胞癌（OSCC）患者中SOX2和SOX9的表达情况，这些患者包括原发性肿瘤、复发性肿瘤及相应的淋巴结转移灶。采用半自动数字病理评分法确定蛋白表达，并进行生存分析以评估其预后意义。

结果

我们发现从原发性疾病到淋巴结转移，SOX9显著下调（p < 0.001）。SOX9表达及SOX2SOX9亚组与较差的总生存期显著相关（p < 0.05）。此外，SOX2SOX9表达模式被确认为总生存期的独立预后因素。

结论

这些结果表明SOX2和SOX9在OSCC患者中具有重要作用，并显示出进一步研究SOX相关基因表达潜在分子机制的临床意义。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10ca/11717967/0059a3ca2d25/HED-47-437-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10ca/11717967/c191111aabff/HED-47-437-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10ca/11717967/4fe05a56b49d/HED-47-437-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10ca/11717967/704c78d8ac93/HED-47-437-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10ca/11717967/eff418fa51ac/HED-47-437-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10ca/11717967/d1ae205f50bf/HED-47-437-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10ca/11717967/57680bf61cdd/HED-47-437-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10ca/11717967/0059a3ca2d25/HED-47-437-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10ca/11717967/c191111aabff/HED-47-437-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10ca/11717967/4fe05a56b49d/HED-47-437-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10ca/11717967/704c78d8ac93/HED-47-437-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10ca/11717967/eff418fa51ac/HED-47-437-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10ca/11717967/d1ae205f50bf/HED-47-437-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10ca/11717967/57680bf61cdd/HED-47-437-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10ca/11717967/0059a3ca2d25/HED-47-437-g002.jpg

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