College of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan 250355, PR China.
Cardiovascular Department of Guang'anmen Hospital Jinan, China Academy of Chinese Medical Sciences, Jinan 250012, China.
J Pharm Pharmacol. 2024 Nov 4;76(11):1404-1430. doi: 10.1093/jpp/rgae105.
Conioselinum anthriscoides (H. Boissieu) Pimenov & Kljuykov, also known as Ligusticum chuanxiong Hort. is a perennial Umbelliferae herb, whose dried rhizome commonly called Chuanxiong Rhizoma. Chuanxiong Rhizoma is widely used in TCM, especially for cardiocerebrovascular and gynecological diseases. However, these studies are scattered and there is no review that can centralize the results of these studies. The authors summarized this review by collecting research results on the chemical, pharmacological, and toxicological of Chuanxiong Rhizoma published in various publications over the past 20 years.
The purpose of this review is to summarize the current experimental studies on Chuanxiong Rhizoma and explore its mechanism of action.
Web of Science, PubMed, CBM, CNKI, Medline, Embase, Elsevier, Springer, Wiley Online Library, Scholar, and other databases were searched, and nearly one hundred experimental studies were collected to summarize this review.
Chuanxiong Rhizoma is composed of essential oil, terpenes, alkaloids, polysaccharide, organic acids, ceramides, and cerebrosides. It has the functions of promoting blood circulation, removing blood stasis, antibacterial, antiviral, and calming the mind to sleep. Now it can be used to treat cardiocerebrovascular and gynecological diseases, neurodegenerative disease, psoriasis, rectal cancer, osteoporosis, and osteoarthritis.
In the past 20 years, a large number of research data have confirmed that Chuanxiong Rhizoma contains rich effective metabolites, has huge medicinal potential, and has a wide range of effective treatments.
川西藁本（H. Boissieu）Pimenov & Kljuykov，又名川芎，是伞形科多年生草本植物，其干燥根茎通常称为川芎根茎。川芎根茎在中医药中广泛应用，尤其用于心脑血管和妇科疾病。然而，这些研究较为分散，没有综述能够集中这些研究的结果。作者通过收集过去 20 年来各种出版物中关于川芎根茎的化学、药理学和毒理学研究结果，对其进行了综述。
本综述的目的是总结川芎根茎的现有实验研究，并探讨其作用机制。
检索了 Web of Science、PubMed、CBM、CNKI、Medline、Embase、Elsevier、Springer、Wiley Online Library、Scholar 和其他数据库，收集了近 100 项实验研究来进行综述。
川芎根茎由挥发油、萜类、生物碱、多糖、有机酸、神经酰胺和脑苷脂组成。它具有促进血液循环、祛瘀、抗菌、抗病毒和镇静安神的作用。现在可用于治疗心脑血管和妇科疾病、神经退行性疾病、银屑病、直肠癌、骨质疏松症和骨关节炎。
在过去的 20 年里，大量的研究数据证实了川芎根茎含有丰富的有效代谢物，具有巨大的药用潜力，并且具有广泛的有效治疗作用。
