Institute of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Lanzhou University, Lanzhou, China.
Institute of Anatomy and Histology & Embryology, Neuroscience, School of Basic Medical Sciences, Lanzhou University, Lanzhou, China.
J Neuroimmune Pharmacol. 2024 Aug 24;19(1):47. doi: 10.1007/s11481-024-10147-5.
The meninges, choroid plexus (CP) and blood-brain barrier (BBB) are recognized as important gateways for peripheral immune cell trafficking into the central nervous system (CNS). Accumulation of peripheral immune cells in brain parenchyma can be observed during aging and Alzheimer's disease (AD). However, the mechanisms by which peripheral immune cells enter the CNS through these three pathways and how they interact with resident cells within the CNS to cause brain injury are not fully understood. In this paper, we review recent research on T cells recruitment in the brain during aging and AD. This review focuses on the possible pathways through which T cells infiltrate the brain, the evidence that T cells are recruited to the brain, and how infiltrating T cells interact with the resident cells in the CNS during aging and AD. Unraveling these issues will contribute to a better understanding of the mechanisms of aging and AD from the perspective of immunity, and hopefully develop new therapeutic strategies for brain aging and AD.
脑膜、脉络丛（CP）和血脑屏障（BBB）被认为是外周免疫细胞进入中枢神经系统（CNS）的重要门户。在衰老和阿尔茨海默病（AD）期间，可以观察到外周免疫细胞在脑实质中的积累。然而，外周免疫细胞通过这三种途径进入中枢神经系统的机制以及它们如何与中枢神经系统内的常驻细胞相互作用导致脑损伤尚不完全清楚。在本文中，我们综述了衰老和 AD 期间大脑中 T 细胞募集的最新研究。本综述重点介绍了 T 细胞浸润大脑的可能途径、T 细胞被招募到大脑的证据，以及浸润 T 细胞在衰老和 AD 期间如何与中枢神经系统内的常驻细胞相互作用。阐明这些问题将有助于从免疫角度更好地理解衰老和 AD 的机制，并有望为大脑衰老和 AD 开发新的治疗策略。
