AkbariRad Mina, Darroudi Susan, Farsi Farima, Mohajer Najme, Ghalibaf AmirAli Moodi, Firoozi Abdollah, Esmaeili Habibollah, Izadi Hanie Salmani, Ghayour-Mobarhan Majid, Moohebati Mohsen
Department of Internal Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Vascular and Endovascular Surgery Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Ir J Med Sci. 2024 Dec;193(6):2705-2711. doi: 10.1007/s11845-024-03791-6. Epub 2024 Aug 24.
People with metabolic syndrome (MetS) are at a higher risk of coronary artery disease, diabetes mellitus, stroke, osteoarthritis, and some types of cancers. Finding markers which are available and inexpensive are most useful for the prediction of MetS. The present study aimed to determine the relationship between atherogenic index and anthropometric indicators and the 10-year risk of MetS.
During the 10-year follow-up on Mashhad stroke and heart atherosclerotic disorder (MASHAD study), 4684 subjects who did not MetS at baseline were recruited in this study. The anthropometric indices and atherogenic index including atherogenic index of plasma (AIP), Castelli's risk index I and II (CRI-I, CRI-I), and atherogenic coefficient (AC) were measured. SPSS-23 was used for all statistical analyses.
Among subjects who did not have MetS at baseline 1599 cases (34.1%) developed MetS. The anthropometric and lipid indices were significantly elevated in patients with MetS compared to the healthy ones (p < 0.001). It was revealed that an increase of one unit in AIP and AC can raise the risk of MetS 22.7% (OR: 1.227 (95% CI, 1.166-1.291)) and 37.7% (OR: 1.377 (95% CI, 1.291-1.468)), respectively. Moreover, increasing one unit of WHtR decreases the risk of MetS by 8.5% (OR: 0.915 (95% CI, 0.886-0.946)).
The results of this longitudinal study showed that increasing AC and AIP could enhance the risk of MetS. The present study also indicated that AC and AIP are useful predictors in the clinical setting for identifying individuals with MetS in the Iranian adult population.
患有代谢综合征（MetS）的人患冠状动脉疾病、糖尿病、中风、骨关节炎和某些类型癌症的风险更高。寻找可用且廉价的标志物对代谢综合征的预测最为有用。本研究旨在确定致动脉粥样硬化指数与人体测量指标以及代谢综合征10年风险之间的关系。
在对马什哈德中风和心脏动脉粥样硬化疾病进行的10年随访期间（马什哈德研究），本研究招募了4684名基线时未患代谢综合征的受试者。测量了人体测量指数和致动脉粥样硬化指数，包括血浆致动脉粥样硬化指数（AIP）、卡斯泰利风险指数I和II（CRI-I、CRI-II）以及致动脉粥样硬化系数（AC）。所有统计分析均使用SPSS-23。
在基线时未患代谢综合征的受试者中，1599例（34.1%）患了代谢综合征。与健康受试者相比，代谢综合征患者的人体测量和血脂指数显著升高（p<0.001）。结果显示，AIP和AC每增加一个单位，代谢综合征的风险分别可提高22.7%（OR：1.227（95%CI，1.166-1.291））和37.7%（OR：1.377（95%CI，1.291-1.468））。此外，腰围身高比每增加一个单位，代谢综合征的风险降低8.5%（OR：0.915（95%CI，0.886-0.946））。
这项纵向研究的结果表明，AC和AIP的增加会增加代谢综合征的风险。本研究还表明，AC和AIP在临床环境中是识别伊朗成年人群中患有代谢综合征个体的有用预测指标。
