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精神分裂症谱系中的自障发生:一种现象学神经发育模型。

Ontogenesis of self-disorders in the schizophrenia spectrum: A phenomenological neuro-developmental model.

机构信息

Department of Mental Health and Pathological Addiction, Child and Adolescent Neuropsychiatry Service, Azienda USL-IRCCS di Reggio Emilia, Reggio Emilia, Italy.

Chair of Psychiatry, Faculty of Biomedical Sciences, Università della Svizzera Italiana, Lugano, Switzerland; Cantonal Sociopsychiatric Organisation, Public Health Division, Department of Health and Social Care, Repubblica e Cantone Ticino, Mendrisio, Switzerland.

出版信息

Schizophr Res. 2024 Oct;272:26-35. doi: 10.1016/j.schres.2024.08.007. Epub 2024 Aug 23.

Abstract

The concept of basic Self-disorders (SD) captures the experiential aspects associated with vulnerability to schizophrenia spectrum disorders (SSD). SD emerge prior to, and constitute the underlying structure for, the emergence of major diagnostic symptoms, including positive psychotic ones. SD are also detectable in populations with familial risk for SSD. This paper proposes a two-stage phenomenological-developmental model, exploring the early deficit in multisensory integration and their impact on the ontogeny of the Minimal Self in the first years of life. It also examines subsequent emergence of schizotaxic vulnerability, which later manifests as typical anomalies of subjectivity, such as basic symptoms and self-disorders.

摘要

基本自我障碍(SD)的概念捕捉到了与精神分裂谱系障碍(SSD)易感性相关的体验方面。SD 先于主要诊断症状的出现,构成其基础结构,包括阳性精神病症状。SD 也可以在 SSD 家族风险人群中检测到。本文提出了一个两阶段的现象学-发展模型,探索了早期多感官整合的缺陷及其对生命头几年最小自我的发生的影响。它还检查了随后出现的精神分裂易损性,后者表现为典型的主体性异常,如基本症状和自我障碍。

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