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自我障碍与精神分裂症谱系:对100例首次住院患者的研究。

Self-disorders and the schizophrenia spectrum: a study of 100 first hospital admissions.

作者信息

Nordgaard Julie, Parnas Josef

机构信息

Psychiatric Center Hvidovre, University of Copenhagen, Broendbyoestervej 160, 2605 Broendby, Denmark;

Psychiatric Center Hvidovre, University of Copenhagen, Broendbyoestervej 160, 2605 Broendby, Denmark; Center for Subjectivity Research Center, University of Copenhagen, Njalsgade 140, 2300 Copenhagen, Denmark.

出版信息

Schizophr Bull. 2014 Nov;40(6):1300-7. doi: 10.1093/schbul/sbt239. Epub 2014 Jan 29.

Abstract

INTRODUCTION

Self-disorders (SD) have been described as a core feature of schizophrenia both in classical and recent psychopathological literature. However, the specificity of SD for the schizophrenia spectrum disorders has never been demonstrated in a diagnostically heterogeneous sample, nor has the concurrent validity of SD been examined.

AIM

(1) To examine the specificity of Examination of Anomalous Self-Experiences (EASE) measured SD to the schizophrenia spectrum disorder in first contact inpatients, (2) to explore the internal consistency and factorial structure of the EASE, (3) to assess the concurrent validity of SD by exploring correlations between SD and the canonical psychopathological dimensions of schizophrenia, (4) to explore relations of SD to intelligence, sociodemographic, and extrinsic illness characteristics.

METHODS

A total of 100 consecutive first admission patients underwent a comprehensive psychopathological examination and an assessment of SD with the EASE scale. The diagnostic distribution of the EASE scores was tested with ANOVA, whereas the relations between the EASE scores and other symptomatic dimensions of schizophrenia were tested with Spearman's rho. A potential factorial structure and the internal consistency of the EASE scale were also examined.

RESULTS

SD aggregated significantly in the schizophrenia spectrum disorders, with no differences between schizophrenia and schizotypal disorders. EASE scores correlated moderately with canonical psychopathological dimensions of schizophrenia. Factor analysis of the EASE disclosed only one factor and the internal consistency of the EASE was excellent.

CONCLUSIONS

SD aggregate selectively in the schizophrenia spectrum disorders, with similar levels in schizophrenia and schizotypy. The study lends validity to the view of SD as an experiential vulnerability phenotype of the schizophrenia spectrum disorders.

摘要

引言

在经典和近期的精神病理学文献中,自我障碍(SD)均被描述为精神分裂症的核心特征。然而,SD在精神分裂症谱系障碍中的特异性从未在诊断异质性样本中得到证实,SD的同时效度也未得到检验。

目的

(1)在首次就诊的住院患者中检验异常自我体验检查(EASE)所测量的SD对精神分裂症谱系障碍的特异性;(2)探索EASE的内部一致性和因子结构;(3)通过探索SD与精神分裂症典型精神病理学维度之间的相关性来评估SD的同时效度;(4)探索SD与智力、社会人口学及外在疾病特征之间的关系。

方法

共100例连续首次入院患者接受了全面的精神病理学检查,并使用EASE量表对SD进行评估。采用方差分析检验EASE评分的诊断分布,而使用斯皮尔曼等级相关检验EASE评分与精神分裂症其他症状维度之间的关系。还对EASE量表的潜在因子结构和内部一致性进行了检验。

结果

SD在精神分裂症谱系障碍中显著聚集,精神分裂症和分裂型障碍之间无差异。EASE评分与精神分裂症的典型精神病理学维度中度相关。EASE的因子分析仅揭示了一个因子,且EASE的内部一致性极佳。

结论

SD在精神分裂症谱系障碍中选择性聚集,在精神分裂症和分裂型障碍中的水平相似。该研究支持了将SD视为精神分裂症谱系障碍的一种体验性易感性表型的观点。

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