Department of Food Science, University of Massachusetts, Amherst, MA 01003, USA.
Department of Food Science, University of Massachusetts, Amherst, MA 01003, USA.
Food Chem. 2024 Dec 15;461:140832. doi: 10.1016/j.foodchem.2024.140832. Epub 2024 Aug 10.
Bioactive components from Porphyra tenera (PT) have been reported to confer various health benefits. The role of PT in inflammatory bowel disease (IBD) has not been fully investigated. This study aimed to explore the anti-inflammatory properties of PT on dextran sodium sulfate (DSS)-treated mice. PT supplementation attenuated the severity of colitis in DSS-treated mice, evidenced by the reduction of disease activity index (DAI), restoration of colonic histological damage and suppression of abnormal inflammatory response. Sequencing analysis indicated that intake of PT alleviated DSS-induced gut microbiota dysbiosis, accompanied by reversing the generation of short-chain fatty acids (SCFAs) and bile acids (BAs). Overall, our findings demonstrated that supplementation of PT attenuated the severity of intestinal inflammation and ameliorated gut microbiota dysbiosis in a murine colitis model, which provided a rationale for further application of edible seaweeds for preventing inflammation-related disorders in humans.
从紫菜（PT）中提取的生物活性成分被报道具有多种健康益处。PT 在炎症性肠病（IBD）中的作用尚未得到充分研究。本研究旨在探讨 PT 对葡聚糖硫酸钠（DSS）处理小鼠的抗炎特性。PT 补充剂可减轻 DSS 处理小鼠结肠炎的严重程度，表现在疾病活动指数（DAI）降低、结肠组织学损伤恢复和异常炎症反应抑制。测序分析表明，PT 的摄入可缓解 DSS 诱导的肠道微生物群失调，同时还可逆转短链脂肪酸（SCFAs）和胆汁酸（BAs）的产生。总的来说，我们的研究结果表明，PT 的补充可减轻小鼠结肠炎模型中肠道炎症的严重程度，并改善肠道微生物群失调，为进一步应用食用海藻预防人类炎症相关疾病提供了依据。
