Givner L B, Edwards M S, Anderson D C, Baker C J
J Infect Dis. 1985 Feb;151(2):217-20. doi: 10.1093/infdis/151.2.217.
Neonates born with less-than-protective levels of transplacentally derived specific antibody are at risk for the development of disease due to type III, group B Streptococcus (III-GBS). The effect of immune serum globulin modified for intravenous use (MISG) on in vitro opsonophagocytosis of III-GBS was evaluated. Cord blood was obtained from 13 healthy, full-term neonates, and bactericidal activity for III-GBS was measured. Before the addition of MISG, one of three serum specimens with moderate levels of antibody to III-GBS, and eight of 10 specimens with low antibody levels demonstrated no bactericidal activity. The mean bactericidal index increased from 27.1% before the addition of MISG to 96.5% with MISG added in a volume equal to that of serum. The effect of MISG on opsonophagocytosis decreased with its dilution in buffer, and no effect was shown at dilutions greater than or equal to 1:4. Thus, MISG can substantially increase in vitro opsonophagocytosis of III-GBS in sera from newborns.
出生时经胎盘获得的特异性抗体水平低于保护水平的新生儿，有因III型B族链球菌（III-GBS）感染而发病的风险。评估了静脉用免疫血清球蛋白（MISG）对III-GBS体外调理吞噬作用的影响。从13名健康足月新生儿获取脐血，并检测其对III-GBS的杀菌活性。在添加MISG之前，三份抗III-GBS抗体水平中等的血清标本中的一份，以及十份抗体水平低的标本中的八份，均未显示出杀菌活性。杀菌指数的平均值从添加MISG前的27.1%增加到添加与血清体积相等的MISG后的96.5%。MISG对调理吞噬作用的影响随其在缓冲液中的稀释而降低，在大于或等于1:4的稀释度下未显示出作用。因此，MISG可显著增加新生儿血清中III-GBS的体外调理吞噬作用。
