分析乳腺癌新标志物 TRPS1 的功能、机制及临床应用前景。

Analysis of the function, mechanism and clinical application prospect of TRPS1, a new marker for breast cancer.

机构信息

Department of Pathology, The First Affiliated Hospital of Zhengzhou University, Jianshe Road 1, Erqi Ward, Zhengzhou, China; College of Basic Medical Sciences, Zhengzhou University, Jianshe Road 1, Erqi Ward, Zhengzhou 450052, China; Henan Key Laboratory of Tumor Pathology, Zhengzhou University, Zhengzhou, China.

出版信息

Gene. 2025 Jan 10;932:148880. doi: 10.1016/j.gene.2024.148880. Epub 2024 Aug 23.

DOI:10.1016/j.gene.2024.148880

PMID:39181273

Abstract

It has been discovered that Trichorhinophalangeal Syndrome-1 (TRPS1), a novel member of the GATA transcription factor family, participates in both normal physiological processes and the development of numerous diseases. Recently, TRPS1 has been identified as a new biomarker to aid in cancer diagnosis and is very common in breast cancer (BC), especially in triple-negative breast cancer (TNBC). In this review, we discussed the structure and function of TRPS1 in various normal cells, focused on its role in tumorigenesis and tumor development, and summarize the research status of TRPS1 in the occurrence and development of BC. We also analyzed the potential use of TRPS1 in guiding clinically personalized precision treatment and the development of targeted drugs.

摘要

现已发现，GATA 转录因子家族的新成员 Trichorhinophalangeal 综合征-1（TRPS1）参与了许多生理过程和疾病的发生。最近，TRPS1 被确定为一种新的生物标志物，有助于癌症的诊断，并且在乳腺癌（BC）中非常常见，尤其是在三阴性乳腺癌（TNBC）中。在本综述中，我们讨论了 TRPS1 在各种正常细胞中的结构和功能，重点讨论了其在肿瘤发生和发展中的作用，并总结了 TRPS1 在 BC 发生和发展中的研究现状。我们还分析了 TRPS1 在指导临床个体化精准治疗和靶向药物开发中的潜在用途。