Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai, 200032, China.
Department of Pathology, Longhua Hospital Shanghai University of Traditional Chinese Medicine, Shanghai, 200032, China.
Diagn Pathol. 2024 Sep 6;19(1):121. doi: 10.1186/s13000-024-01542-w.
We explored Trichorhinophalangeal syndrome type 1 (TRPS1) expression in special types of breast carcinoma, and analyzed the correlation between TRPS1 and androgen receptor (AR) expression in triple-negative breast cancer (TNBC).
TRPS1 expression was analyzed in 801 patients with special types of breast carcinoma. A total of 969 TNBC were used to analyze the correlation between the expression of TRPS1 and AR. TRPS1 expression was evaluated in 1975 cases of breast cancer with different molecular types.
A total of 801 special types of breast cancers were stained with TRPS1.TRPS1 was positive in 100% (63/63) of mucinous carcinoma, 100% (7/7) adenoid cystic carcinomas (4 classic adenoid cystic carcinomas and 3 solid-basaloid adenoid cystic carcinomas), 100% (4/4) tubular carcinomas, 100% (2/2) secretory carcinomas, and 99.59% (243/244) invasive lobular carcinomas, 99.26% (267/269) invasive micropapillary carcinomas, 97.44% (38/39) ER-positive neuroendocrine tumors, 94.44% (34/36) metaplastic breast carcinomas (MBCs), 63.73% (65/102) apocrine carcinomas. TRPS1 was negative in all triple-negative neuroendocrine carcinomas (0/7).TRPS1 was positive in 92.86% (26/28) of metastatic special types of breast cancer. TRPS1 and AR expression were analyzed in 969 cases of TNBC. 90.40% were positive for TRPS1, and 42.41% were positive for AR. A significant inverse correlation between TRPS1 and AR expression was shown in TNBC (p < .001). TRPS1 showed a higher positive rate (93.13%) in TNBC compared to GATA binding protein 3 (GATA3), gross cystic disease fluid protein 15 (GCDFP-15) and forkhead box transcription Factor C 1 (FOXC1).
In conclusion, our study demonstrated that TRPS1 is a highly sensitive marker for most special types of breast carcinoma. TRPS1 was positive in 63.73% of apocrine carcinomas. TRPS1 and AR expression was inversely correlated in TNBC.
我们探讨了 1 型 Trichorhinophalangeal 综合征（TRPS1）在特殊类型乳腺癌中的表达，并分析了三阴性乳腺癌（TNBC）中 TRPS1 与雄激素受体（AR）表达的相关性。
分析了 801 例特殊类型乳腺癌患者的 TRPS1 表达情况。共分析了 969 例 TNBC，以分析 TRPS1 和 AR 表达之间的相关性。对不同分子类型的 1975 例乳腺癌评估了 TRPS1 的表达。
801 例特殊类型乳腺癌中进行了 TRPS1 染色。黏液癌 100%（63/63）、腺样囊性癌 100%（7/7）（4 例经典腺样囊性癌和 3 例实体基底样腺样囊性癌）、管状癌 100%（4/4）、分泌癌 100%（2/2）和 99.59%（243/244）浸润性小叶癌、99.26%（267/269）浸润性微乳头状癌、97.44%（38/39）ER 阳性神经内分泌肿瘤、94.44%（34/36）间变性乳腺癌（MBC）、63.73%（65/102）大汗腺癌均为阳性。所有三阴性神经内分泌癌（0/7）均为 TRPS1 阴性。28 例转移性特殊类型乳腺癌中 TRPS1 阳性率为 92.86%（26/28）。在 969 例 TNBC 中分析了 TRPS1 和 AR 的表达，90.40%为 TRPS1 阳性，42.41%为 AR 阳性。TNBC 中 TRPS1 和 AR 表达呈显著负相关（p < .001）。TRPS1 在 TNBC 中的阳性率（93.13%）高于 GATA 结合蛋白 3（GATA3）、总囊液蛋白 15（GCDFP-15）和叉头框转录因子 C1（FOXC1）。
总之，本研究表明 TRPS1 是大多数特殊类型乳腺癌的高度敏感标志物。大汗腺癌中 TRPS1 阳性率为 63.73%。TRPS1 和 AR 在 TNBC 中表达呈负相关。
