多瘤病毒感染与肺癌的关系：系统评价和荟萃分析。
Association of polyomavirus infection with lung cancer: A systematic review and meta-analysis.
机构信息
Faculty of Pharmacy, Middle East University, Amman 11831, Jordan.
Department of Pharmacy, Al-Noor University College, Nineveh, Iraq.
出版信息
Pathol Res Pract. 2024 Oct;262:155521. doi: 10.1016/j.prp.2024.155521. Epub 2024 Aug 10.
AIM
The objective of this study was to investigate the pooled prevalence and possible association between polyomavirus infection and lung cancer.
METHODS
A systematic publication search was conducted by identifying relevant cross-sectional and case-control studies from major online databases. Heterogeneity, OR, and corresponding 95 % CI were applied to all studies through meta-analysis and forest plot. Random effects models were used to calculate the overall pooled prevalence. Visual inspection of a funnel plot plotting the log-transformed OR and its associated standard error of the log (OR) was combined with the Begg and Egger test to examine the presence and influence of publication bias. Analyzes were performed using Stata software v.14.1.
RESULTS
23 articles (33 datasets) were included in the meta-analysis, of which 14 datasets were case/control and the rest were cross-sectional studies. The pooled polyomavirus infection rate in lung cancer patients was 0.06 % (0.02-0.11 %). In subgroup analysis, the pooled prevalence of JCV, MCPyV, KI, SV40, BKV, WU, MU, and STL was 21 %, 7 %, 6 %, 2 %, 0 %, 0 %, 0 %, and 0 % respectively. An association has been found between polyomavirus infection and lung cancer [summary OR 6.33 (95 % CI (1.76-22.77); I2=67.45 %)]. The subgroup analysis, based on the virus type, showed a strong association between MCPyV and lung cancer [summary OR 13.61 (95 % CI 2.41-76.59; I2=40.0 %)]. despite the high prevalence of JCV DNA in lung cancer tissue, analysis of case-control studies showed that JCV is not associated with lung cancer and does not increase the risk of lung cancer.
CONCLUSION
This study showed a significant association between polyomaviruses infection with lung cancer. The results also revealed a pooled prevalence of 6 % for polyomaviruses in lung tumor patients. Altogether, the findings of the present work suggest that Merkel cell polyomavirus infection is a potential risk factor for lung cancer.
目的
本研究旨在调查多瘤病毒感染与肺癌之间的合并患病率及可能的关联。
方法
通过从主要在线数据库中确定相关的横断面和病例对照研究，进行系统的文献检索。通过荟萃分析和森林图，应用异质性、OR 和相应的 95%CI 对所有研究进行分析。使用随机效应模型计算总体合并患病率。通过绘制以对数转换 OR 及其相关标准误差（OR）为纵坐标的漏斗图，结合 Begg 和 Egger 检验，检查发表偏倚的存在和影响。使用 Stata 软件 v.14.1 进行分析。
结果
纳入了荟萃分析的 23 篇文章（33 个数据集），其中 14 个数据集为病例对照研究，其余为横断面研究。肺癌患者的多瘤病毒感染率为 0.06%（0.02-0.11%）。在亚组分析中，JCV、MCPyV、KI、SV40、BKV、WU、MU 和 STL 的合并患病率分别为 21%、7%、6%、2%、0%、0%、0%和 0%。多瘤病毒感染与肺癌之间存在关联[汇总 OR 6.33（95%CI（1.76-22.77））；I2=67.45%]。基于病毒类型的亚组分析显示，MCPyV 与肺癌之间存在强烈关联[汇总 OR 13.61（95%CI 2.41-76.59；I2=40.0%）]。尽管肺癌组织中 JCV DNA 的高流行率，但病例对照研究的分析表明 JCV 与肺癌无关，不会增加肺癌的风险。
结论
本研究表明多瘤病毒感染与肺癌之间存在显著关联。研究结果还显示，肺癌肿瘤患者中多瘤病毒的合并患病率为 6%。总的来说，本研究工作的结果表明，默克尔细胞多瘤病毒感染是肺癌的一个潜在危险因素。
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