Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, 106 Zhongshaner Road, Guangzhou, Guangdong 519041, China.
Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, 106 Zhongshaner Road, Guangzhou, Guangdong 519041, China.
Eur J Prev Cardiol. 2023 Jul 12;30(9):832-843. doi: 10.1093/eurjpc/zwad060.
AIMS: To investigate the joint association of accelerometer-measured physical activity (PA) and sleep duration with mortality risk. METHODS AND RESULTS: A 7-day accelerometer recording was performed on 92 221 participants (age 62.4 ± 7.8 years; 56.4% women) from the UK Biobank between February 2013 and December 2015. We divided sleep duration into three groups (short, normal, and long), total volume of PA into three levels according to tertiles (high, intermediate, low), and moderate-to-vigorous PA (MVPA) into two groups based on the World Health Organization guidelines. The mortality outcomes were prospectively collected through the death registry. Over a median follow-up of 7.0 years, 3080 adults died, of which 1074 died from cardiovascular disease (CVD) and 1871 from cancer. The associations of PA and sleep duration with mortality risk were all in a curvilinear dose-response pattern (Pnonlinearity <0.001). PA and sleep duration had additive and multiplicative interactions on mortality risk (Pinteraction <0.05). Compared with the participants with guideline-recommended MVPA and normal sleep duration, those without recommended MVPA but having short or long sleep duration were at a higher risk for all-cause mortality [short sleep: hazard ratio (HR) = 1.88; 95% confidence interval (CI), 1.61-2.20; long sleep: HR = 1.69; 95% CI, 1.49-1.90]. A higher volume of PA or recommended MVPA attenuated the detrimental effects of short or long sleep duration on all-cause and CVD mortality risks. CONCLUSION: MVPA meeting recommendations or a higher volume of PA at any intensity potentially diminished the adverse effects on all-cause and cause-specific mortality associated with short and long sleep duration.
目的：研究加速度计测量的身体活动 (PA) 和睡眠时间与死亡率风险的联合关联。
方法和结果：2013 年 2 月至 2015 年 12 月，英国生物银行对 92221 名参与者（年龄 62.4±7.8 岁；56.4%为女性）进行了为期 7 天的加速度计记录。我们将睡眠时长分为三组（短、正常和长），根据三分位法将 PA 总量分为三个水平（高、中、低），并根据世界卫生组织指南将中等到剧烈 PA（MVPA）分为两组。死亡率结果通过死亡登记处进行前瞻性收集。在中位随访 7.0 年后，3080 名成年人死亡，其中 1074 人死于心血管疾病（CVD），1871 人死于癌症。PA 和睡眠时长与死亡率风险的关系均呈曲线剂量反应模式（P 非线性<0.001）。PA 和睡眠时长对死亡率风险有相加和相乘的交互作用（P 交互<0.05）。与具有指南推荐的 MVPA 和正常睡眠时长的参与者相比，没有推荐的 MVPA 但睡眠时长较短或较长的参与者全因死亡率风险更高[短睡眠：风险比（HR）=1.88；95%置信区间（CI），1.61-2.20；长睡眠：HR=1.69；95%CI，1.49-1.90]。更高的 PA 量或任何强度的推荐 MVPA 减轻了短或长睡眠时长对全因和 CVD 死亡率风险的不利影响。
结论：符合建议的 MVPA 或任何强度的更高 PA 量可能会降低与短时间和长时间睡眠相关的全因和特定原因死亡率的不利影响。
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