Matucci M, Messori A, Donati-Cori G, Longo G, Vannini S, Morfini M, Tendi E, Rossi-Ferrini P L
Scand J Haematol. 1985 Jan;34(1):22-8. doi: 10.1111/j.1600-0609.1985.tb00739.x.
Single-dose kinetics of 4 Factor VIII concentrates (Kryobulin, Hemofil T, Koate, cryoprecipitate) were studied in 41 patients with haemophilia-A. Model-independent methods were adopted for calculating the kinetic parameters (area under the curve, clearance, area under the moment curve, mean residence time, volume of distribution at steady-state). No substantial difference was observed in the kinetic characteristics of the 4 Factor VIII concentrates. A considerable interindividual variability of the calculated kinetic parameters was demonstrated for all concentrates. Our findings support the need to individualize Factor VIII dosage.
对41例甲型血友病患者研究了4种凝血因子VIII浓缩剂（冷沉淀球蛋白、海莫费尔T、科亚特、冷沉淀）的单剂量动力学。采用非模型方法计算动力学参数（曲线下面积、清除率、矩曲线下面积、平均驻留时间、稳态分布容积）。4种凝血因子VIII浓缩剂的动力学特征未观察到实质性差异。所有浓缩剂计算出的动力学参数均显示出相当大的个体间变异性。我们的研究结果支持凝血因子VIII剂量个体化的必要性。
