Messori A, Longo G, Morfini M, Donati-Cori G, Matucci M, Ruffo S, Tendi E, Vannini S
J Clin Hosp Pharm. 1984 Jun;9(2):95-103. doi: 10.1111/j.1365-2710.1984.tb01065.x.
The usefulness of a calculator programme that enables individualization of the dosage of Factor VIII, based on the concentration-time data measured after a test-dose, was assessed. The programme was tested in 12 haemophiliacs who required multiple-dose treatment with Factor VIII. Individual kinetic parameters were estimated in each patient from the plasma level data following the test-dose. Then, each patient received the multiple dose treatment with Factor VIII according to the dosage regimen suggested by the calculator programme. The time-curve of Factor VIII plasma levels at steady state was predicted by using the kinetic variables previously estimated. The plasma levels of Factor VIII were measured in all patients at steady state. As a result, good agreement between predicted and measured steady state concentrations was observed (r2 = 0.9797; P less than 0.001). The calculator programme tested in the present study appears to be a useful tool for individualizing the dosage regimen of Factor VIII in haemophiliacs.
对一个计算器程序的实用性进行了评估，该程序能够根据试验剂量后测得的浓度-时间数据实现凝血因子VIII剂量的个体化。该程序在12名需要接受凝血因子VIII多剂量治疗的血友病患者中进行了测试。根据试验剂量后的血浆水平数据估算每位患者的个体动力学参数。然后，每位患者按照计算器程序建议的给药方案接受凝血因子VIII多剂量治疗。利用先前估算的动力学变量预测稳态时凝血因子VIII血浆水平的时间曲线。在所有患者的稳态时测量凝血因子VIII的血浆水平。结果发现，预测的和测量的稳态浓度之间具有良好的一致性（r2 = 0.9797；P<0.001）。本研究中测试的计算器程序似乎是使血友病患者凝血因子VIII给药方案个体化的有用工具。
