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尼日利亚奥韦里联邦大学教学医院感染 HIV 儿童的营养状况:城乡居民的前瞻性分析。

Nutritional status of HIV-infected children at Federal University Teaching Hospital, Owerri, Nigeria: A prospective analysis of rural and urban dwellers.

机构信息

Federal University Teaching Hospital, Owerri, Nigeria.

出版信息

Medicine (Baltimore). 2024 Aug 23;103(34):e39413. doi: 10.1097/MD.0000000000039413.

Abstract

Malnutrition is a critical concern among children living with human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS), particularly in regions heavily affected by the HIV epidemic, such as sub-Saharan Africa. In 2019, nearly 2.84 million children under 19 years of age were living with HIV globally, with over 90% residing in sub-Saharan Africa. Concurrently, malnutrition remains prevalent in the region, with approximately 49 million children under the age of 5 experiencing stunting and 149 million suffering from wasting in 2018. This burden of malnutrition is exacerbated by factors such as poverty, food insecurity, and HIV/AIDS, which collectively contribute to adverse health outcomes among affected children. The bidirectional relationship between HIV/AIDS and malnutrition is well-established, with HIV infection increasing the risk of malnutrition and malnutrition worsening the progression of HIV/AIDS. Studies have consistently demonstrated higher rates of stunting, underweight, and wasting among HIV-infected children compared to their uninfected counterparts. Moreover, malnutrition significantly impacts the disease progression, morbidity, and mortality of HIV-infected individuals, further underscoring the importance of addressing this issue in pediatric HIV care. A total of 99 HIV-infected children, aged 2 to 16 years, were consecutively recruited from the pediatric infectious disease clinic of the Federal University Teaching Hospital Owerri. Anthropometric measurements, including weight and height, were obtained using a stadiometer (RGZ-160 England). Weight status was categorized as normal, underweight, overweight, or obese, while height status was classified as stunted, normal, or tall stature. The study participants ranged in age from 2 to 16 years. Approximately 20.2% of the children were underweight, and 6.1% were classified as obese. Stunting was observed in 29.3% of the participants. Notably, all forms of malnutrition, including underweight and overweight, were more prevalent among children residing in rural areas. In addition, stunting was more common among rural dwellers. This study highlights the high prevalence of malnutrition among HIV-infected children attending the pediatric infectious disease clinic at the Federal University Teaching Hospital Owerri. The findings underscore the urgent need for targeted nutritional interventions, particularly in rural areas, to improve the health outcomes of HIV-infected children.

摘要

在感染人类免疫缺陷病毒(HIV)/获得性免疫缺陷综合征(AIDS)的儿童中,营养不良是一个严重的问题,特别是在受 HIV 疫情影响严重的地区,如撒哈拉以南非洲。2019 年,全球有近 284 万名 19 岁以下的儿童感染 HIV,其中 90%以上居住在撒哈拉以南非洲。与此同时,该地区营养不良仍然普遍存在,2018 年约有 4900 万名 5 岁以下儿童发育迟缓,1.49 亿名儿童消瘦。贫困、粮食不安全和 HIV/AIDS 等因素使营养不良问题更加严重,这些因素共同导致受影响儿童的健康状况恶化。HIV/AIDS 和营养不良之间的双向关系是明确的,HIV 感染增加了营养不良的风险,而营养不良又使 HIV/AIDS 的进展恶化。研究表明,与未感染者相比,HIV 感染者的发育迟缓、体重不足和消瘦率更高。此外,营养不良显著影响 HIV 感染者的疾病进展、发病率和死亡率,进一步强调了在儿科 HIV 护理中解决这一问题的重要性。

本研究共纳入了 99 名年龄在 2 至 16 岁的 HIV 感染儿童,这些儿童均来自奥韦里联邦大学教学医院儿科传染病门诊。使用测高计(RGZ-160 英国)测量体重和身高等人体测量学指标。根据体重将体重状况分为正常、体重不足、超重或肥胖,根据身高将身高状况分为发育迟缓、正常或高身材。研究参与者的年龄在 2 至 16 岁之间。大约 20.2%的儿童体重不足,6.1%的儿童超重。29.3%的参与者存在发育迟缓。值得注意的是,所有形式的营养不良,包括体重不足和超重,在农村地区的儿童中更为普遍。此外,农村居民中发育迟缓更为常见。

本研究强调了在奥韦里联邦大学教学医院儿科传染病门诊就诊的 HIV 感染儿童中营养不良的高患病率。研究结果强调了在农村地区需要有针对性的营养干预措施,以改善 HIV 感染儿童的健康结果。

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