Department of Pediatric Allergy and Immunology, İstanbul University-Cerrahpaşa, Cerrahpaşa Faculty of Medicine, İstanbul, Türkiye
Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Necker Hospital for Sick Children, Paris, France
Balkan Med J. 2024 Sep 6;41(5):326-332. doi: 10.4274/balkanmedj.galenos.2024.2024-8-18. Epub 2024 Aug 26.
In recent decades, the prevalence of inborn errors of immunity has increased, necessitating the development of more effective treatment and care options for these highly morbid conditions. Due to these “experiments of nature,” the complicated nature of the immune system is being revealed. Based on the functional and molecular tests, targeted therapies are now being developed which offer a more effective approach and reduce damage. This study aimed to investigate a key cytokine of the cellular immune response, interferon‐gamma (IFN-γ), which is linked to Mendelian susceptibility to Mycobacterial disease, and its potential as a therapeutic option for IFN-γ deficiency.
近几十年来，先天性免疫缺陷的发病率不断上升，因此需要开发更有效的治疗和护理方案来应对这些高度病态的疾病。由于这些“自然实验”，免疫系统的复杂性逐渐被揭示。目前正在根据功能和分子检测结果开发靶向治疗方法，以期提供更有效的治疗方法并减少损伤。本研究旨在研究细胞免疫反应的关键细胞因子干扰素-γ（IFN-γ），它与孟德尔对分枝杆菌病易感性有关，及其作为 IFN-γ 缺乏症治疗选择的潜力。
